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Pathogens 2016, 5(1), 24;

Urinary Tract Infection Molecular Mechanisms and Clinical Translation

Department of Microbiology, Immunology and Glycobiology (MIG), Institute of Laboratory Medicine, Lund University, 221 00 Lund, Sweden
Author to whom correspondence should be addressed.
Academic Editor: Lawrence S. Young
Received: 12 November 2015 / Revised: 5 February 2016 / Accepted: 5 February 2016 / Published: 24 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
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Rapid developments in infection biology create new and exciting options for individualized diagnostics and therapy. Such new practices are needed to improve patient survival and reduce morbidity. Molecular determinants of host resistance to infection are being characterized, making it possible to identify susceptible individuals and to predict their risk for future morbidity. Immunotherapy is emerging as a new strategy to treat infections worldwide and controlled boosting of the host immune defense represents an important therapeutic alternative to antibiotics. In proof of concept studies, we have demonstrated that this approach is feasible. The long-term goal is not just to remove the pathogens but to also develop technologies that restore resistance to infection in disease-prone patients and devise personalized therapeutic interventions. Here, we discuss some approaches to reaching these goals, in patients with urinary tract infection (UTI). We describe critical host signaling pathways that define symptoms and pathology and the genetic control of innate immune responses that balance protection against tissue damage. For some of these genes, human relevance has been documented in clinical studies, identifying them as potential targets for immune-modulatory therapies, as a complement to antibiotics. View Full-Text
Keywords: immunomodulation; genetics; innate immunity; urinary tract infection; susceptibility immunomodulation; genetics; innate immunity; urinary tract infection; susceptibility

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Godaly, G.; Ambite, I.; Puthia, M.; Nadeem, A.; Ho, J.; Nagy, K.; Huang, Y.; Rydström, G.; Svanborg, C. Urinary Tract Infection Molecular Mechanisms and Clinical Translation. Pathogens 2016, 5, 24.

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