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Open AccessArticle

Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages

1
Institute of Experimental Immunology and Imaging, Department Immunodynamics, University Hospital Essen, University Duisburg-Essen, Essen 45141, Germany
2
Institute of Experimental Immunology, University Hospital Bonn, Bonn 53127, Germany
*
Author to whom correspondence should be addressed.
Academic Editor: Catharina Svanborg
Pathogens 2016, 5(1), 15; https://doi.org/10.3390/pathogens5010015
Received: 16 July 2015 / Revised: 28 January 2016 / Accepted: 28 January 2016 / Published: 4 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
The antibacterial defense against infections depends on the cooperation between distinct phagocytes of the innate immune system, namely macrophages and neutrophils. However, the mechanisms driving this cooperation are incompletely understood. In this study we describe the crosstalk between Ly6C+ and Ly6C macrophage-subtypes and neutrophils in the context of urinary tract infection (UTI) with uropathogenic E. coli (UPEC). Ly6C macrophages acted as tissue resident sentinels and attracted circulating phagocytes by chemokines. Ly6C+ macrophages produced tumor necrosis factor (TNF) that licensed Ly6C macrophages to release preformed CXCL2, which in turn caused matrix metalloproteinases (MMP-9) secretion by neutrophils to enable transepithelial migration. View Full-Text
Keywords: crosstalk; transepithelial migration; Ly6C+ and Ly6C macrophages; neutrophils; uropathogenic E. coli (UPEC) crosstalk; transepithelial migration; Ly6C+ and Ly6C macrophages; neutrophils; uropathogenic E. coli (UPEC)
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MDPI and ACS Style

Zec, K.; Volke, J.; Vijitha, N.; Thiebes, S.; Gunzer, M.; Kurts, C.; Engel, D.R. Neutrophil Migration into the Infected Uroepithelium Is Regulated by the Crosstalk between Resident and Helper Macrophages. Pathogens 2016, 5, 15.

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