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Pathogens 2016, 5(1), 17;

First Description of Infection of Caprine Herpesvirus 1 (CpHV-1) in Goats in Mainland France

Anses, Sophia-Antipolis Laboratory, 105 Route des Chappes, BP111, 06902 Sophia-Antipolis, France
Coopérative de l’Agneau de Haute-Provence, 04000 Digne Les Bains, France
Alpes-Maritimes Veterinary Laboratory, 06902 Sophia-Antipolis, France
Pyrénées-Tarbes Laboratory, Centre des Affaires Kennedy, 65000 Tarbes, France
Ariège Veterinary Laboratory, Rue las Escoumes, 09008 Foix, France
Aveyron Labo, 12031 Rodez, France
Tarn Analytical Laboratory, 81011 Albi, France
Savoie Analytical Laboratory, 73024 Chambéry, France
Anses, Niort Laboratory, 79012 Niort, France
Author to whom correspondence should be addressed.
Received: 31 October 2015 / Accepted: 29 January 2016 / Published: 6 February 2016
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The purpose of this study was to investigate the epidemiological situation of the caprine herpesvirus 1 (CpHV-1) infection in nine districts in mainland France, mostly in the south, near Italy or Spain, where high seroprevalence has been observed. Two more central areas were also included in the study. The serosurvey was carried out in 9564 goats (275 herds) using bovine herpesvirus 1 (BoHV-1) glycoprotein B and E ELISAs. To confirm the presence of specific CpHV-1 antibodies, some of the samples were tested in neutralization assay. Results demonstrate, for the first time, CpHV-1 infection in goat herds on the French mainland. The analysis found cases of alphaherpesviruses infection in each district studied, with different levels of seroprevalence observed within each district (ranging from 0.2% to 31.56% at an individual level and from 9% to 46.2% for herd seroprevalence). Moreover, in the Alpes-Maritimes district, the seroprevalence seemed to be higher in older goats (79.45% of animals 6 years old or more) than in younger animals (40.99% of one-year-olds). This result suggests frequent virus re-excretion and circulation in herds. Results analysis also shows that the seroprevalence was higher when the herd size increased. In addition, the first French CpHV-1 strain was isolated from nasal swabs taken on an infected goat. The data reported herein demonstrate that CpHV-1 circulates in mainland France, which should henceforth be taken into consideration in cases of unexplained abortion in goats. View Full-Text
Keywords: CpHV-1; caprine; Herpes; goat; epidemiology; France mainland CpHV-1; caprine; Herpes; goat; epidemiology; France mainland

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Suavet, F.; Champion, J.-L.; Bartolini, L.; Bernou, M.; Alzieu, J.-P.; Brugidou, R.; Darnatigues, S.; Reynaud, G.; Perrin, C.; Adam, G.; Thiéry, R.; Duquesne, V. First Description of Infection of Caprine Herpesvirus 1 (CpHV-1) in Goats in Mainland France. Pathogens 2016, 5, 17.

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