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First Description of Infection of Caprine Herpesvirus 1 (CpHV-1) in Goats in Mainland France

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Anses, Sophia-Antipolis Laboratory, 105 Route des Chappes, BP111, 06902 Sophia-Antipolis, France
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Coopérative de l’Agneau de Haute-Provence, 04000 Digne Les Bains, France
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Alpes-Maritimes Veterinary Laboratory, 06902 Sophia-Antipolis, France
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Pyrénées-Tarbes Laboratory, Centre des Affaires Kennedy, 65000 Tarbes, France
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Ariège Veterinary Laboratory, Rue las Escoumes, 09008 Foix, France
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Aveyron Labo, 12031 Rodez, France
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Tarn Analytical Laboratory, 81011 Albi, France
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Savoie Analytical Laboratory, 73024 Chambéry, France
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Anses, Niort Laboratory, 79012 Niort, France
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Author to whom correspondence should be addressed.
Pathogens 2016, 5(1), 17; https://doi.org/10.3390/pathogens5010017
Received: 31 October 2015 / Accepted: 29 January 2016 / Published: 6 February 2016
The purpose of this study was to investigate the epidemiological situation of the caprine herpesvirus 1 (CpHV-1) infection in nine districts in mainland France, mostly in the south, near Italy or Spain, where high seroprevalence has been observed. Two more central areas were also included in the study. The serosurvey was carried out in 9564 goats (275 herds) using bovine herpesvirus 1 (BoHV-1) glycoprotein B and E ELISAs. To confirm the presence of specific CpHV-1 antibodies, some of the samples were tested in neutralization assay. Results demonstrate, for the first time, CpHV-1 infection in goat herds on the French mainland. The analysis found cases of alphaherpesviruses infection in each district studied, with different levels of seroprevalence observed within each district (ranging from 0.2% to 31.56% at an individual level and from 9% to 46.2% for herd seroprevalence). Moreover, in the Alpes-Maritimes district, the seroprevalence seemed to be higher in older goats (79.45% of animals 6 years old or more) than in younger animals (40.99% of one-year-olds). This result suggests frequent virus re-excretion and circulation in herds. Results analysis also shows that the seroprevalence was higher when the herd size increased. In addition, the first French CpHV-1 strain was isolated from nasal swabs taken on an infected goat. The data reported herein demonstrate that CpHV-1 circulates in mainland France, which should henceforth be taken into consideration in cases of unexplained abortion in goats. View Full-Text
Keywords: CpHV-1; caprine; Herpes; goat; epidemiology; France mainland CpHV-1; caprine; Herpes; goat; epidemiology; France mainland
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Suavet, F.; Champion, J.-L.; Bartolini, L.; Bernou, M.; Alzieu, J.-P.; Brugidou, R.; Darnatigues, S.; Reynaud, G.; Perrin, C.; Adam, G.; Thiéry, R.; Duquesne, V. First Description of Infection of Caprine Herpesvirus 1 (CpHV-1) in Goats in Mainland France. Pathogens 2016, 5, 17.

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