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Novel Strategies in the Prevention and Treatment of Urinary Tract Infections
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Genetic Variations in Vesicoureteral Reflux Sequelae

Innate Immunity Translational Research Center, Children’s Foundation Research Institute, Le Bonheur Children’s Hospital, Memphis, TN 38103, USA
Department of Pediatrics, Nationwide Children’s Hospital, Columbus, OH 43205, USA
Author to whom correspondence should be addressed.
Academic Editor: Catharina Svanborg
Pathogens 2016, 5(1), 14;
Received: 11 September 2015 / Revised: 20 January 2016 / Accepted: 21 January 2016 / Published: 2 February 2016
(This article belongs to the Special Issue Molecular Aspects of Urinary Tract Infection)
Urinary tract infections (UTI) are a common condition in children. Vesicoureteral reflux (VUR) represents a common associated condition with childhood UTI. UTI susceptibility appears to have a genetic component based on family and UTI cohort studies. Targeted analysis of innate immune system genetic variations indicate that these variations are important in UTI susceptibility. In this overview, we discuss how current cohorts and genetic strategies can be implemented to discover new susceptibility loci in patients with UTI. View Full-Text
Keywords: vesicoureteral reflux; genetics; copy number variations; urinary tract infections vesicoureteral reflux; genetics; copy number variations; urinary tract infections
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Hains, D.S.; Schwaderer, A.L. Genetic Variations in Vesicoureteral Reflux Sequelae. Pathogens 2016, 5, 14.

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