Full Genomic Characterization of a Saffold Virus Isolated in Peru
by
Mariana Leguia 1,*, Steev Loyola 1, Jane Rios 1, Diana Juarez 1, Carolina Guevara 1, Maria Silva 1, Karla Prieto 2, Michael Wiley 2, Matthew R. Kasper 1, Gustavo Palacios 2
and Daniel G. Bausch 3
Mariana Leguia 1,*, Steev Loyola 1, Jane Rios 1, Diana Juarez 1, Carolina Guevara 1, Maria Silva 1, Karla Prieto 2, Michael Wiley 2, Matthew R. Kasper 1, Gustavo Palacios 2 and Daniel G. Bausch 3
1
Naval Medical Research Unit No. 6 (NAMRU-6), Callao 2, Peru
2
Center for Genome Sciences, United States Army Medical Research Institute for Infectious Diseases (USAMRIID), Frederick, MD 21702, USA
3
Naval Medical Research Unit No. 6 (NAMRU-6), Callao 2, Peru
*
Author to whom correspondence should be addressed.
Academic Editor: Marek L. Kowalski
Pathogens 2015, 4(4), 816-825; https://doi.org/10.3390/pathogens4040816
Received: 30 September 2015 / Accepted: 17 November 2015 / Published: 20 November 2015
(This article belongs to the Special Issue Respiratory Pathogens)
While studying respiratory infections of unknown etiology we detected Saffold virus in an oropharyngeal swab collected from a two-year-old female suffering from diarrhea and respiratory illness. The full viral genome recovered by deep sequencing showed 98% identity to a previously described Saffold strain isolated in Japan. Phylogenetic analysis confirmed the Peruvian Saffold strain belongs to genotype 3 and is most closely related to strains that have circulated in Asia. This is the first documented case report of Saffold virus in Peru and the only complete genomic characterization of a Saffold-3 isolate from the Americas.
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Keywords:
Saffold virus; Cardiovirus; full genome; Peru
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Leguia, M.; Loyola, S.; Rios, J.; Juarez, D.; Guevara, C.; Silva, M.; Prieto, K.; Wiley, M.; Kasper, M.R.; Palacios, G.; Bausch, D.G. Full Genomic Characterization of a Saffold Virus Isolated in Peru. Pathogens 2015, 4, 816-825.
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