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Pathogens 2014, 3(2), 280-308;

Leptospiral Pathogenomics

Division of Infectious Diseases, Department of Medicine, University of California San Diego, School of Medicine, La Jolla, CA 92093-0741, USA
Instituto de Medicine Tropical "Alexander von Humboldt", Department of Cellular and Molecular Sciences, Faculty of Sciences and Laboratory of Research and Development, Universidad Peruana Cayetano Heredia, Lima 100, Peru
Craig Venter Institute, Rockville, MD 20850, USA
Author to whom correspondence should be addressed.
Received: 18 January 2014 / Revised: 22 March 2014 / Accepted: 28 March 2014 / Published: 10 April 2014
(This article belongs to the Special Issue Bacterial Pathogenomics: From Technology to Application)
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Leptospirosis, caused by pathogenic spirochetes belonging to the genus Leptospira, is a zoonosis with important impacts on human and animal health worldwide. Research on the mechanisms of Leptospira pathogenesis has been hindered due to slow growth of infectious strains, poor transformability, and a paucity of genetic tools. As a result of second generation sequencing technologies, there has been an acceleration of leptospiral genome sequencing efforts in the past decade, which has enabled a concomitant increase in functional genomics analyses of Leptospira pathogenesis. A pathogenomics approach, by coupling of pan-genomic analysis of multiple isolates with sequencing of experimentally attenuated highly pathogenic Leptospira, has resulted in the functional inference of virulence factors. The global Leptospira Genome Project supported by the U.S. National Institute of Allergy and Infectious Diseases to which key scientific contributions have been made from the international leptospirosis research community has provided a new roadmap for comprehensive studies of Leptospira and leptospirosis well into the future. This review describes functional genomics approaches to apply the data generated by the Leptospira Genome Project towards deepening our knowledge of virulence factors of Leptospira using the emerging discipline of pathogenomics. View Full-Text
Keywords: Leptospira; pathogenomics; virulence; genomics; evolution; taxonomy; molecular epidemiology; systems biology Leptospira; pathogenomics; virulence; genomics; evolution; taxonomy; molecular epidemiology; systems biology

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This is an open access article distributed under the Creative Commons Attribution License (CC BY 3.0).

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Lehmann, J.S.; Matthias, M.A.; Vinetz, J.M.; Fouts, D.E. Leptospiral Pathogenomics. Pathogens 2014, 3, 280-308.

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