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Volume 14
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10.3390/pathogens14090874
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Review

Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment

by
Jianchang Huang
1,2,
Ailin Zhang
1,2,
Jialin Sun
3,
Yuhan Fu
1,2,
Weinan Li
1,2,* and
Yanhong Wang
1,2,*
1
School of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin 150040, China
2
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China
3
Department of Medicine, Heilongjiang Minzu College, Harbin 150066, China
*
Authors to whom correspondence should be addressed.
Pathogens 2025, 14(9), 874; https://doi.org/10.3390/pathogens14090874
Submission received: 17 June 2025 / Revised: 22 August 2025 / Accepted: 29 August 2025 / Published: 2 September 2025
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Abstract

Malignant tumors have become one of the most important diseases threatening human life and health, and the prevention and treatment of cancer have always been the direction of modern medicine’s continuous exploration. According to modern medical research, a tumor microbial ecosystem exists in all human cancers. With the continuous deepening of research on the tumor microenvironment (TME), it has been discovered that some specific bacteria cause tumor production and development by damaging DNA, activating oncogenic signaling pathways, suppressing anti-tumor immunity, and producing pro-tumor metabolites. Certain bacteria associated with tumors can also serve as breakthroughs in the prevention and treatment of tumors. In this review, we present and summarize evidence from a large number of studies on the effects of oncobacteria on tumor prevention and treatment, and we further discuss the direction in which oncobacteria can be positively and effectively used in tumor therapy.
Keywords: bacteria; tumors; prevention; treatment bacteria; tumors; prevention; treatment

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MDPI and ACS Style

Huang, J.; Zhang, A.; Sun, J.; Fu, Y.; Li, W.; Wang, Y. Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment. Pathogens 2025, 14, 874. https://doi.org/10.3390/pathogens14090874

AMA Style

Huang J, Zhang A, Sun J, Fu Y, Li W, Wang Y. Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment. Pathogens. 2025; 14(9):874. https://doi.org/10.3390/pathogens14090874

Chicago/Turabian Style

Huang, Jianchang, Ailin Zhang, Jialin Sun, Yuhan Fu, Weinan Li, and Yanhong Wang. 2025. "Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment" Pathogens 14, no. 9: 874. https://doi.org/10.3390/pathogens14090874

APA Style

Huang, J., Zhang, A., Sun, J., Fu, Y., Li, W., & Wang, Y. (2025). Bacteria-Based Roles in Solid Tumors: Potential for Prevention and Treatment. Pathogens, 14(9), 874. https://doi.org/10.3390/pathogens14090874

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