Concurrent Leydig and Sertoli Cell Tumors Associated with Testicular Mycosis in a Dog: A Case Report and Literature Review
Abstract
1. Introduction
2. Materials and Methods
3. Discussion and Conclusions
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- Clinical analysis and laboratory test results: Morphological, biochemical, serological, and other;
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- Collection of various biological materials from patients for mycological evaluation: Blood, cerebrospinal fluid, and fluids from the pleural cavity, peritoneum, and joints; material from cysts, abscesses, and puncture of the paranasal sinuses; samples from the lower respiratory tract (e.g., sputum); samples obtained during surgical procedures, endoscopy, or fine-needle aspiration biopsy; swabs from the oral cavity, pharynx, nasal cavities, and larynx; content from the genital organs, for example, from the urethra, urine, and others;
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- Direct techniques are the simplest diagnostic method, and sometimes, they are decisive, such as in Pneumocystis carinii or Rhinosporidium seeberi infections;
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- Stained preparations: smears, histopathological preparations;
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- Cultures—Material collected for testing for the presence of fungi is inoculated onto liquid or solid media—containing protein, carbohydrates, and other components—directly in the amount of 0.5–1.5 cm3. Tissues or biopsy specimens are homogenized or ground by shaking with sterile beads; materials collected during biopsy are simultaneously inoculated onto solid or liquid Sabouraud media or broth agar;
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- Other techniques include fluorescence, immunohistochemistry, immunofluorescence, and in situ hybridization. Immunohistochemical tests with monoclonal antibodies (WF-AF-1, EB-A1), immunofluorescence, and in situ hybridization are also used in diagnostics to determine the genus and species, especially in cases where it is not possible to culture fungi [3,13,14,16].
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
HE | Hematoxylin and eosin (stain) |
HIV | Human immunodeficiency virus |
HPF | High-power field |
ICT | Interstitial cell tumor |
SCT | Sertoli cell tumor |
SEM | Seminoma |
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Kuberka, M.; Prządka, P.; Dzimira, S. Concurrent Leydig and Sertoli Cell Tumors Associated with Testicular Mycosis in a Dog: A Case Report and Literature Review. Pathogens 2025, 14, 752. https://doi.org/10.3390/pathogens14080752
Kuberka M, Prządka P, Dzimira S. Concurrent Leydig and Sertoli Cell Tumors Associated with Testicular Mycosis in a Dog: A Case Report and Literature Review. Pathogens. 2025; 14(8):752. https://doi.org/10.3390/pathogens14080752
Chicago/Turabian StyleKuberka, Mirosław, Przemysław Prządka, and Stanisław Dzimira. 2025. "Concurrent Leydig and Sertoli Cell Tumors Associated with Testicular Mycosis in a Dog: A Case Report and Literature Review" Pathogens 14, no. 8: 752. https://doi.org/10.3390/pathogens14080752
APA StyleKuberka, M., Prządka, P., & Dzimira, S. (2025). Concurrent Leydig and Sertoli Cell Tumors Associated with Testicular Mycosis in a Dog: A Case Report and Literature Review. Pathogens, 14(8), 752. https://doi.org/10.3390/pathogens14080752