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10.3390/pathogens12050678
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Article

Differential Protein Expression of Taenia crassiceps ORF Strain in the Murine Cysticercosis Model Using Resistant (C57BL/6) Mice

by
Lucía Jiménez
1,†,
Mariana Díaz-Zaragoza
1,2,*,†,
Magdalena Hernández
3,
Luz Navarro
4,
Ricardo Hernández-Ávila
5,
Sergio Encarnación-Guevara
3,
Pedro Ostoa-Saloma
5 and
Abraham Landa
1,*
1
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, A.P. 70228, Mexico City 04510, Mexico
2
Departamento de Ciencias de la Salud, Centro Universitario de los Valles, Universidad de Guadalajara, Carretera Guadalajara-Ameca Km. 45.5, Guadalajara 46600, Mexico
3
Centro de Ciencias Genómicas, Universidad Nacional Autónoma de México, Av. Universidad 565, Chamilpa, Cuernavaca 62210, Mexico
4
Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad Universitaria, A.P. 70228, Mexico City 04510, Mexico
5
Departamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria, A.P. 70228, Mexico City 04510, Mexico
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work and share first authorship.
Pathogens 2023, 12(5), 678; https://doi.org/10.3390/pathogens12050678
Submission received: 23 March 2023 / Revised: 28 April 2023 / Accepted: 29 April 2023 / Published: 4 May 2023
(This article belongs to the Special Issue Advances in the Immunobiology of Parasitic Diseases Volume II)
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Abstract

A cysticercosis model of Taenia crassiceps ORF strain in susceptible BALB/c mice revealed a Th2 response after 4 weeks, allowing for the growth of the parasite, whereas resistant C57BL/6 mice developed a sustained Th1 response, limiting parasitic growth. However, little is known about how cysticerci respond to an immunological environment in resistant mice. Here, we show that the Th1 response, during infection in resistant C57BL/6 mice, lasted up to 8 weeks and kept parasitemia low. Proteomics analysis of parasites during this Th1 environment showed an average of 128 expressed proteins; we chose 15 proteins whose differential expression varied between 70 and 100%. A total of 11 proteins were identified that formed a group whose expression increased at 4 weeks and decreased at 8 weeks, and another group with proteins whose expression was high at 2 weeks and decreased at 8 weeks. These identified proteins participate in tissue repair, immunoregulation and parasite establishment. This suggests that T. crassiceps cysticerci in mice resistant under the Th1 environment express proteins that control damage and help to establish a parasite in the host. These proteins could be targets for drugs or vaccine development.
Keywords: Taenia crassiceps; cysticerci; Th1 response; C57BL/6 mouse; proteomics Taenia crassiceps; cysticerci; Th1 response; C57BL/6 mouse; proteomics

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MDPI and ACS Style

Jiménez, L.; Díaz-Zaragoza, M.; Hernández, M.; Navarro, L.; Hernández-Ávila, R.; Encarnación-Guevara, S.; Ostoa-Saloma, P.; Landa, A. Differential Protein Expression of Taenia crassiceps ORF Strain in the Murine Cysticercosis Model Using Resistant (C57BL/6) Mice. Pathogens 2023, 12, 678. https://doi.org/10.3390/pathogens12050678

AMA Style

Jiménez L, Díaz-Zaragoza M, Hernández M, Navarro L, Hernández-Ávila R, Encarnación-Guevara S, Ostoa-Saloma P, Landa A. Differential Protein Expression of Taenia crassiceps ORF Strain in the Murine Cysticercosis Model Using Resistant (C57BL/6) Mice. Pathogens. 2023; 12(5):678. https://doi.org/10.3390/pathogens12050678

Chicago/Turabian Style

Jiménez, Lucía, Mariana Díaz-Zaragoza, Magdalena Hernández, Luz Navarro, Ricardo Hernández-Ávila, Sergio Encarnación-Guevara, Pedro Ostoa-Saloma, and Abraham Landa. 2023. "Differential Protein Expression of Taenia crassiceps ORF Strain in the Murine Cysticercosis Model Using Resistant (C57BL/6) Mice" Pathogens 12, no. 5: 678. https://doi.org/10.3390/pathogens12050678

APA Style

Jiménez, L., Díaz-Zaragoza, M., Hernández, M., Navarro, L., Hernández-Ávila, R., Encarnación-Guevara, S., Ostoa-Saloma, P., & Landa, A. (2023). Differential Protein Expression of Taenia crassiceps ORF Strain in the Murine Cysticercosis Model Using Resistant (C57BL/6) Mice. Pathogens, 12(5), 678. https://doi.org/10.3390/pathogens12050678

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