Next Article in Journal
Successful Removal of Angiostrongylus cantonensis Larvae from the Central Nervous System of Rats 7- and 14-Days Post-Infection Using a Product Containing Moxidectin, Sarolaner and Pyrantel Embonate (Simparica Trio™) in Experimental Infections
Previous Article in Journal
ADP-Ribosylation in Antiviral Innate Immune Response
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Pathogens
Volume 12
Issue 2
10.3390/pathogens12020304
pathogens-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Case Report

Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination

by
Andrea Marino
1,2,
Maddalena Calvo
3,*,
Laura Trovato
1,3,
Guido Scalia
1,3,
Maria Gussio
2,
Ugo Consoli
4,
Manuela Ceccarelli
2,
Giuseppe Nunnari
5 and
Bruno Cacopardo
2
1
Department of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, Italy
2
Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, Italy
3
U.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-Vittorio Emanuele”, Via S. Sofia 78, 95123 Catania, Italy
4
Unità Operativa Complessa (UOC) di Ematologia, ARNAS Garibaldi Hospital, 95122 Catania, Italy
5
Unit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, Italy
*
Author to whom correspondence should be addressed.
Pathogens 2023, 12(2), 304; https://doi.org/10.3390/pathogens12020304
Submission received: 10 January 2023 / Revised: 25 January 2023 / Accepted: 10 February 2023 / Published: 12 February 2023
(This article belongs to the Section Fungal Pathogens)
Browse Figures
Review Reports Versions Notes

Abstract

Hematological diseases, especially those causing severe neutropenia, represent the main factor in the development of invasive fungal infections (IFIs). Furthermore, COVID-19 has been considerably associated with IFIs due to immunological dysregulation, prolonged hospitalization in intensive care units, and immunomodulatory therapies. Opportunistic molds are correlated with elevated morbidity and mortality rates in these patients, due to immune impairment, diagnostic complexity, and therapeutic challenges. Among opportunistic fungal infections, the Mucorales and Fusarium species are considered particularly aggressive, especially during severe neutropenia. A mixed Mucorales/Fusarium infection has been rarely described in scientific literature. Herein, we report a case of Mucorales and Fusarium co-infection in a patient with acute leukemia whose clinical history was also complicated by COVID-19. Herein, we report a challenging case in order to encourage the clinical suspicion of combined fungal infections in immunosuppressed patients, performing a punctual microbiological diagnosis, and promptly administering the correct empiric and targeted antifungal therapy.
Keywords: invasive fungal infections; Fusarium infections; Fusarium/Mucorales infections; antifungal stewardship invasive fungal infections; Fusarium infections; Fusarium/Mucorales infections; antifungal stewardship

Share and Cite

MDPI and ACS Style

Marino, A.; Calvo, M.; Trovato, L.; Scalia, G.; Gussio, M.; Consoli, U.; Ceccarelli, M.; Nunnari, G.; Cacopardo, B. Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination. Pathogens 2023, 12, 304. https://doi.org/10.3390/pathogens12020304

AMA Style

Marino A, Calvo M, Trovato L, Scalia G, Gussio M, Consoli U, Ceccarelli M, Nunnari G, Cacopardo B. Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination. Pathogens. 2023; 12(2):304. https://doi.org/10.3390/pathogens12020304

Chicago/Turabian Style

Marino, Andrea, Maddalena Calvo, Laura Trovato, Guido Scalia, Maria Gussio, Ugo Consoli, Manuela Ceccarelli, Giuseppe Nunnari, and Bruno Cacopardo. 2023. "Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination" Pathogens 12, no. 2: 304. https://doi.org/10.3390/pathogens12020304

APA Style

Marino, A., Calvo, M., Trovato, L., Scalia, G., Gussio, M., Consoli, U., Ceccarelli, M., Nunnari, G., & Cacopardo, B. (2023). Mucorales/Fusarium Mixed Infection in Hematologic Patient with COVID-19 Complications: An Unfortunate Combination. Pathogens, 12(2), 304. https://doi.org/10.3390/pathogens12020304

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop