Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans
Abstract
:1. Introduction
2. Methods
2.1. Macrophages
2.2. Fungi
2.3. Macrophage–Yeast Interactions
2.4. SAP and Other Additives
2.5. The SAP-Competitor Compounds
2.6. Pro-Amyloid and Anti-Amyloid Peptides
2.7. Flow Cytometry
2.8. Statistics
3. Results
3.1. Compounds That Inhibit SAP Binding to Macrophages Enhance Phagocytosis
3.2. ‘Seeding’ Amyloid on the Yeast Surface Enhances Phagocytosis of Yeasts
3.3. Miridesap Successfully Removes SAP from the Yeast Cell Surface
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
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Klotz, S.A.; Bradley, N.; Lipke, P.N. Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans. Pathogens 2022, 11, 1000. https://doi.org/10.3390/pathogens11091000
Klotz SA, Bradley N, Lipke PN. Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans. Pathogens. 2022; 11(9):1000. https://doi.org/10.3390/pathogens11091000
Chicago/Turabian StyleKlotz, Stephen A., Nicole Bradley, and Peter N. Lipke. 2022. "Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans" Pathogens 11, no. 9: 1000. https://doi.org/10.3390/pathogens11091000
APA StyleKlotz, S. A., Bradley, N., & Lipke, P. N. (2022). Blocking Serum Amyloid-P Component from Binding to Macrophages and Augmenting Fungal Functional Amyloid Increases Macrophage Phagocytosis of Candida albicans. Pathogens, 11(9), 1000. https://doi.org/10.3390/pathogens11091000