Extracellular Vesicles Derived from Allergen Immunotherapy-Treated Mice Suppressed IL-5 Production from Group 2 Innate Lymphoid Cells
Abstract
:1. Introduction
2. Results
2.1. Effects of SCIT on the Development of AHR and IL-5 Production in BALF
2.2. Phenotypes of EVs Derived from Sera of Non-SCIT-Treated and SCIT-Treated Asthmatic Mice
2.3. Effects of EVs on IL-5 Production from ILC2s
3. Discussion
4. Materials and Methods
4.1. Sensitization, SCIT, and Challenges
4.2. Measurement of AHR
4.3. Quantitative Analysis of IL-5 in BALF
4.4. Isolation of EVs
4.5. Analyses of CD9 and CD63 Expression Levels and Particle Sizes of EVs
4.6. Effect of EVs on IL-5 Production from ILC2s
4.7. Statistical Analyses
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Matsuda, M.; Shimizu, S.; Kitatani, K.; Nabe, T. Extracellular Vesicles Derived from Allergen Immunotherapy-Treated Mice Suppressed IL-5 Production from Group 2 Innate Lymphoid Cells. Pathogens 2022, 11, 1373. https://doi.org/10.3390/pathogens11111373
Matsuda M, Shimizu S, Kitatani K, Nabe T. Extracellular Vesicles Derived from Allergen Immunotherapy-Treated Mice Suppressed IL-5 Production from Group 2 Innate Lymphoid Cells. Pathogens. 2022; 11(11):1373. https://doi.org/10.3390/pathogens11111373
Chicago/Turabian StyleMatsuda, Masaya, Seito Shimizu, Kazuyuki Kitatani, and Takeshi Nabe. 2022. "Extracellular Vesicles Derived from Allergen Immunotherapy-Treated Mice Suppressed IL-5 Production from Group 2 Innate Lymphoid Cells" Pathogens 11, no. 11: 1373. https://doi.org/10.3390/pathogens11111373