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Six-Month Follow-Up after Vaccination with BNT162b2: SARS-CoV-2 Antigen-Specific Cellular and Humoral Immune Responses in Hemodialysis Patients and Kidney Transplant Recipients

1
Department of Nephrology, I. Department of Medicine, University Medical Center Mainz, Johannes Gutenberg University, D 55131 Mainz, Germany
2
Department of General, Visceral and Transplantation Surgery, University Medical Center Mainz, Johannes Gutenberg University, D 55131 Mainz, Germany
3
Blood Transfusion Center, University Medical Center Mainz, Johannes-Gutenberg University, D 55131 Mainz, Germany
4
Department of Internal Medicine, University Medical Center Mainz, Johannes Gutenberg University, D 55131 Mainz, Germany
5
Research Center of Immunotherapy (FZI), University Medical Center Mainz, Johannes Gutenberg University, D 55131 Mainz, Germany
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work and share last authorship.
Academic Editor: Xuguang Li
Pathogens 2022, 11(1), 67; https://doi.org/10.3390/pathogens11010067
Received: 10 December 2021 / Revised: 30 December 2021 / Accepted: 2 January 2022 / Published: 5 January 2022
(This article belongs to the Section Viral Pathogens)
Hemodialysis patients (HDP) and kidney transplant recipients (KTR) have a high risk of infection with SARS-CoV-2 with poor clinical outcomes. Because of this, vaccination of these groups of patients against SARS-CoV-2 is particularly important. However, immune responses may be impaired in immunosuppressed and chronically ill patients. Here, our aim was to compare the efficacy of an mRNA-based vaccine in HDP, KTR, and healthy subjects. Design: In this prospective observational cohort study, the humoral and cellular response of prevalent 192 HDP, 50 KTR, and 28 healthy controls (HC) was assessed 1, 2, and 6 months after the first immunization with the BNT162b2 mRNA vaccine. Results: After 6 months, 97.5% of HDP, 37.9% of KTR, and 100% of HC had an antibody response. Median antibody levels were 1539.7 (±3355.8), 178.5 (±369.5), and 2657.8 (±2965.8) AU/mL in HDP, KTR, and HC, respectively (p ≤ 0.05). A SARS-CoV-2 antigen-specific cell response to vaccination was found in 68.8% of HDP, 64.5% of KTR, and 90% of HC. Conclusion: The humoral response rates to mRNA-based vaccination of HDPs are comparable to HCs, but antibody titers are lower. Furthermore, HDPs have weaker T-cell response to vaccination than HCs. KTRs have very low humoral and antigen-specific cellular response rates and antibody titers, which requires other vaccination strategies in addition to booster vaccination. View Full-Text
Keywords: COVID-19; transplantation; immunosuppression; end-stage kidney disease COVID-19; transplantation; immunosuppression; end-stage kidney disease
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MDPI and ACS Style

Boedecker-Lips, S.C.; Lautem, A.; Runkel, S.; Klimpke, P.; Kraus, D.; Keil, P.; Holtz, S.; Tomalla, V.; Marczynski, P.; Boedecker, C.B.; Galle, P.R.; Koch, M.; Weinmann-Menke, J. Six-Month Follow-Up after Vaccination with BNT162b2: SARS-CoV-2 Antigen-Specific Cellular and Humoral Immune Responses in Hemodialysis Patients and Kidney Transplant Recipients. Pathogens 2022, 11, 67. https://doi.org/10.3390/pathogens11010067

AMA Style

Boedecker-Lips SC, Lautem A, Runkel S, Klimpke P, Kraus D, Keil P, Holtz S, Tomalla V, Marczynski P, Boedecker CB, Galle PR, Koch M, Weinmann-Menke J. Six-Month Follow-Up after Vaccination with BNT162b2: SARS-CoV-2 Antigen-Specific Cellular and Humoral Immune Responses in Hemodialysis Patients and Kidney Transplant Recipients. Pathogens. 2022; 11(1):67. https://doi.org/10.3390/pathogens11010067

Chicago/Turabian Style

Boedecker-Lips, Simone C., Anja Lautem, Stefan Runkel, Pascal Klimpke, Daniel Kraus, Philipp Keil, Stefan Holtz, Vanessa Tomalla, Paul Marczynski, Christian B. Boedecker, Peter R. Galle, Martina Koch, and Julia Weinmann-Menke. 2022. "Six-Month Follow-Up after Vaccination with BNT162b2: SARS-CoV-2 Antigen-Specific Cellular and Humoral Immune Responses in Hemodialysis Patients and Kidney Transplant Recipients" Pathogens 11, no. 1: 67. https://doi.org/10.3390/pathogens11010067

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