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Review

Hepatitis E Virus in Croatia in the “One-Health” Context

1
Department of Gastroenterology and Hepatology, University Hospital Center Zagreb, 10000 Zagreb, Croatia
2
School of Medicine, University of Zagreb, 10000 Zagreb, Croatia
3
Department of Virology, Croatian Veterinary Institute, 10000 Zagreb, Croatia
4
Poultry Center, Croatian Veterinary Institute, 10000 Zagreb, Croatia
5
Department of Gastroenterology and Endocrinology, General Hospital “Dr. Josip Bencevic”, 35000 Slavonski Brod, Croatia
6
Department of Epidemiology, Croatian Institute of Public Health, 10000 Zagreb, Croatia
7
Department of Medicine, Merkur University Hospital, 10000 Zagreb, Croatia
8
Department of Anestesiology, Reanimatology and Intensive Care, Merkur University Hospital, 10000 Zagreb, Croatia
9
Department of Abdominal and Transplant Surgery, Merkur University Hospital, 10000 Zagreb, Croatia
10
Department of Virology, Croatian Institute of Public Health, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Pathogens 2021, 10(6), 699; https://doi.org/10.3390/pathogens10060699
Submission received: 14 May 2021 / Revised: 1 June 2021 / Accepted: 2 June 2021 / Published: 4 June 2021
(This article belongs to the Special Issue Emerging and Neglected Viruses and Zoonoses)

Abstract

Hepatitis E virus (HEV) is the most common cause of viral hepatitis globally. The first human case of autochthonous HEV infection in Croatia was reported in 2012, with the undefined zoonotic transmission of HEV genotype 3. This narrative review comprehensively addresses the current knowledge on the HEV epidemiology in humans and animals in Croatia. Published studies showed the presence of HEV antibodies in different population groups, such as chronic patients, healthcare professionals, voluntary blood donors and professionally exposed and pregnant women. The highest seroprevalence in humans was found in patients on hemodialysis in a study conducted in 2018 (27.9%). Apart from humans, different studies have confirmed the infection in pigs, wild boars and a mouse, indicating the interspecies transmission of HEV due to direct or indirect contact or as a foodborne infection. Continued periodical surveys in humans and animals are needed to identify the possible changes in the epidemiology of HEV infections.
Keywords: hepatitis E virus; One-Health; Croatia; epidemiology; human; animal; serology; molecular testing; phylogenetic analysis hepatitis E virus; One-Health; Croatia; epidemiology; human; animal; serology; molecular testing; phylogenetic analysis

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MDPI and ACS Style

Mrzljak, A.; Jemersic, L.; Savic, V.; Balen, I.; Ilic, M.; Jurekovic, Z.; Pavicic-Saric, J.; Mikulic, D.; Vilibic-Cavlek, T. Hepatitis E Virus in Croatia in the “One-Health” Context. Pathogens 2021, 10, 699. https://doi.org/10.3390/pathogens10060699

AMA Style

Mrzljak A, Jemersic L, Savic V, Balen I, Ilic M, Jurekovic Z, Pavicic-Saric J, Mikulic D, Vilibic-Cavlek T. Hepatitis E Virus in Croatia in the “One-Health” Context. Pathogens. 2021; 10(6):699. https://doi.org/10.3390/pathogens10060699

Chicago/Turabian Style

Mrzljak, Anna, Lorena Jemersic, Vladimir Savic, Ivan Balen, Maja Ilic, Zeljka Jurekovic, Jadranka Pavicic-Saric, Danko Mikulic, and Tatjana Vilibic-Cavlek. 2021. "Hepatitis E Virus in Croatia in the “One-Health” Context" Pathogens 10, no. 6: 699. https://doi.org/10.3390/pathogens10060699

APA Style

Mrzljak, A., Jemersic, L., Savic, V., Balen, I., Ilic, M., Jurekovic, Z., Pavicic-Saric, J., Mikulic, D., & Vilibic-Cavlek, T. (2021). Hepatitis E Virus in Croatia in the “One-Health” Context. Pathogens, 10(6), 699. https://doi.org/10.3390/pathogens10060699

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