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Article

Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs

1
Department of Virology, National Veterinary Research Institute, 24-100 Pulawy, Poland
2
School of Veterinary Science, Massey University, Palmerston North 4442, New Zealand
3
School of Agriculture and Environment, Massey University, Palmerston North 4442, New Zealand
*
Author to whom correspondence should be addressed.
Academic Editor: Jochen Bodem
Pathogens 2021, 10(3), 322; https://doi.org/10.3390/pathogens10030322
Received: 2 February 2021 / Revised: 4 March 2021 / Accepted: 6 March 2021 / Published: 9 March 2021
(This article belongs to the Special Issue Epidemiology, Surveillance and Control of Infectious Diseases)
Equid herpesvirus 5 (EHV-5) is one of two γ-herpesviruses that commonly infect horses worldwide. The objective of the study was to estimate the genetic variability within EHV-5 viruses circulating among horses in Poland. Partial glycoprotein B (gB) sequences from 92 Polish horses from 13 studs throughout Poland were compared to each other and to three EHV-5 sequences from other countries. Despite the overall high level of conservation, considerable variability was observed around the putative furin cleavage site. Based on phylogenetic analysis, the viruses clustered within two major lineages (A and B), with further sub-clustering within group A. The clustering of EHV-5 sequences was independent of age or geographical origin of the sampled horses. Recombination was identified as one of the factors contributing to the genomic heterogeneity. Viruses from unweaned foals were more similar to viruses from other foals at the same stud than to viruses form their dams, suggesting the horizontal transfer and/or evolution of EHV-5 within individual hosts. Our data indicate that the gB sequence is not suitable for tracking the source of EHV-5 infection. Further research is needed to elucidate the importance of the sequence variability around the EHV-5 gB furin cleavage site on the biology of the virus. View Full-Text
Keywords: equid herpesvirus 5; genetic variability; glycoprotein B; phylogeny equid herpesvirus 5; genetic variability; glycoprotein B; phylogeny
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MDPI and ACS Style

Stasiak, K.; Dunowska, M.; Trewick, S.; Rola, J. Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs. Pathogens 2021, 10, 322. https://doi.org/10.3390/pathogens10030322

AMA Style

Stasiak K, Dunowska M, Trewick S, Rola J. Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs. Pathogens. 2021; 10(3):322. https://doi.org/10.3390/pathogens10030322

Chicago/Turabian Style

Stasiak, Karol, Magdalena Dunowska, Steven Trewick, and Jerzy Rola. 2021. "Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs" Pathogens 10, no. 3: 322. https://doi.org/10.3390/pathogens10030322

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