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Epigenomes
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16 November 2025

Epigenetic Regulation of Salt Stress Responses in Rice: Mechanisms and Prospects for Enhancing Tolerance

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Department of Biology, Ecology and Earth Sciences (DiBEST), Unit of Plant Biology, University of Calabria, 87036 Rende, Italy
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Department of Agricultural and Environmental Sciences—Production, Landscape, Agroenergy (Di.S.A.A.), University of Milano, 20133 Milano, Italy
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Author to whom correspondence should be addressed.
Epigenomes2025, 9(4), 46;https://doi.org/10.3390/epigenomes9040046 
(registering DOI)

Abstract

Rice (Oryza sativa L.) is a staple food for over half the global population and a model organism for monocot plant research. However, it is susceptible to salinity, with most cultivated varieties showing reduced growth at salt levels above 3 dS/m. Despite numerous efforts to improve its salt tolerance, little progress has been made. A promising area of research lies in the study of epigenetic regulation, which encompasses DNA methylation, histone modifications, and chromatin remodelling. These processes play a crucial role in mediating how plants respond to salt stress by modulating gene expression. This often results in heritable changes that can be used as molecular markers. Studies in rice and other cereals have demonstrated a clear association between histone alterations, shifts in DNA methylation patterns, and the expression of salt-responsive genes. Furthermore, epigenetic mechanisms contribute to the development of stress memory, enabling plants to respond more effectively to recurring stressful conditions. Understanding these regulatory pathways offers new opportunities for breeding or engineering salt-tolerant rice varieties, potentially leading to improved crop resilience and productivity under saline conditions.

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