I outline the history of and progress in observing and understanding quasar multi-frequency and multi-messenger variability from the point of view of someone who has been working in the field for over 30 years. I will present some important references for the evolution from optical monitoring to multi-frequency cooperative programs that revealed the true multi-frequency/multi-timescale nature of variability in these objects. Quasar observations began with separate radio and optical monitoring programs; then the optical and radio observations w ere combined. This was followed by expanding the analyses to include far IR, UV, X-rays, and finally adding gamma rays. This progression yielded simultaneous multi-frequency spectra of these objects and light curves over 15 decades in frequency. The future is adding particle (neutrino) and gravitational waves to the picture. I also present long-term (50 years) optical light curves, and discuss optical variability at all timescales from minutes to tens of years in some selected objects for which we have reliable long-term monitoring observations.
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