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Warfarin: The End or the End of One Size Fits All Therapy?

Department of Molecular and Clinical Pharmacology, Wolfson Centre for Personalised Medicine, University of Liverpool, Liverpool L69 3GL, UK
J. Pers. Med. 2018, 8(3), 22; https://doi.org/10.3390/jpm8030022
Received: 7 May 2018 / Revised: 24 June 2018 / Accepted: 25 June 2018 / Published: 28 June 2018
(This article belongs to the Special Issue Cytochrome P450 Variation in Pharmacogenomics)
Oral anticoagulants are required for both treatment and prophylaxis in many different diseases. Clinicians and patients now have a choice of oral anticoagulants, including the vitamin K antagonists (of which warfarin is the most widely used and is used as the exemplar in this paper), and direct oral anticoagulants (DOACs: dabigatran, apixaban, rivaroxaban, and edoxaban). This paper explores the recent advances and controversies in oral anticoagulation. While some commentators may favour a complete switchover to DOACs, this paper argues that warfarin still has a place in therapy, and a stratified approach that enables the correct choice of both drug and dose would improve both patient outcomes and affordability. View Full-Text
Keywords: warfarin; vitamin K antagonists; direct oral anticoagulants; dabigatran; rivaroxaban; apixaban; edoxaban; pharmacogenomics; personalized medicine; therapeutic drug monitoring warfarin; vitamin K antagonists; direct oral anticoagulants; dabigatran; rivaroxaban; apixaban; edoxaban; pharmacogenomics; personalized medicine; therapeutic drug monitoring
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Pirmohamed, M. Warfarin: The End or the End of One Size Fits All Therapy? J. Pers. Med. 2018, 8, 22.

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