Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach
Abstract
1. Introduction
2. Methods
3. Results
3.1. Approved Systemic Therapies for Advanced BCC
3.1.1. Hedgehog Pathway Inhibitors
3.1.2. Vismodegib
3.1.3. Sonidegib
3.1.4. Immune-Checkpoint Inhibitors
3.2. Neoadjuvant Therapies Under Investigation for Advanced BCC
3.2.1. Hedgehog Pathway Inhibitors
3.2.2. Immune-Checkpoint Inhibitors
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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NCT | Title of the Study | Phase | Intervention | Status |
---|---|---|---|---|
Hedgehog pathway inhibitors | ||||
NCT02667574 | Study Evaluating the Interest of Vismodegib as Neo-adjuvant Treatment of Basal Cell Carcinoma (BCC) (VISMONEO) | Phase II | Vismodegib Surgery | Completed |
NCT03534947 | A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma (SONIB) | Phase II | Sonidegib Imiquimod Surgery | Recruiting |
Immune-checkpoint inhibitors | ||||
NCT05929664 | Cemiplimab for the Treatment of Locally Advanced Head and Neck Basal Cell Carcinoma Before Surgery | Phase II | Cemiplimab Surgery | Recruiting |
NCT04323202 | Neoadjuvant-Adjuvant Pembrolizumab in Resectable Advanced Basal Cell Carcinoma of Head&Neck | Phase I | Pembrolizumab Surgery | Active, not recruiting |
NCT06624475 | Neoadjuvant Opdualag Versus Nivolumab for Resectable High-Risk Basal Cell Carcinoma | Phase II | Nivolumab Relatlimab Surgery | Not yet recruiting |
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Paradisi, A.; Mannino, M.; Brunetti, F.; Bocchino, E.; Di Stefani, A.; Peris, K. Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach. J. Pers. Med. 2025, 15, 226. https://doi.org/10.3390/jpm15060226
Paradisi A, Mannino M, Brunetti F, Bocchino E, Di Stefani A, Peris K. Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach. Journal of Personalized Medicine. 2025; 15(6):226. https://doi.org/10.3390/jpm15060226
Chicago/Turabian StyleParadisi, Andrea, Maria Mannino, Francesco Brunetti, Enrico Bocchino, Alessandro Di Stefani, and Ketty Peris. 2025. "Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach" Journal of Personalized Medicine 15, no. 6: 226. https://doi.org/10.3390/jpm15060226
APA StyleParadisi, A., Mannino, M., Brunetti, F., Bocchino, E., Di Stefani, A., & Peris, K. (2025). Advanced Basal Cell Carcinoma: A Narrative Review on Current Systemic Treatments and the Neoadjuvant Approach. Journal of Personalized Medicine, 15(6), 226. https://doi.org/10.3390/jpm15060226