Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

Lamberti, Nicola; Traina, Luca; Savriè, Caterina; Tsolaki, Elpiniki; Rinaldo, Natascia; Straudi, Sofia; Guerzoni, Franco; Napoli, Nicola; Manfredini, Roberto; Gasbarro, Vincenzo; Manfredini, Fabio

doi:10.3390/jpm13040636

Open AccessArticle

Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

by

Nicola Lamberti

¹

,

Luca Traina

²,

Caterina Savriè

³,

Elpiniki Tsolaki

²

,

Natascia Rinaldo

¹

,

Sofia Straudi

^1,4

,

Franco Guerzoni

⁵,

Nicola Napoli

⁵,

Roberto Manfredini

^3,6,7,*

,

Vincenzo Gasbarro

^2,7 and

Fabio Manfredini

^1,4

¹

Department of Neuroscience and Rehabilitation, University of Ferrara, Via L. Borsari 46, 44121 Ferrara, Italy

²

Unit of Vascular and Endovascular Surgery, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy

³

Clinica Medica Unit, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy

⁴

Unit of Rehabilitation Medicine, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy

⁵

Health Statistics Unit, University Hospital of Ferrara, Via Aldo Moro 8, 44124 Ferrara, Italy

⁶

University Center for Studies on Gender Medicine, Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, 64/B, 44121 Ferrara, Italy

⁷

Department of Medical Sciences, University of Ferrara, Via Fossato di Mortara, 64/B, 44121 Ferrara, Italy

^*

Author to whom correspondence should be addressed.

J. Pers. Med. 2023, 13(4), 636; https://doi.org/10.3390/jpm13040636

Submission received: 17 March 2023 / Revised: 31 March 2023 / Accepted: 5 April 2023 / Published: 5 April 2023

(This article belongs to the Special Issue Personalized Medicine Interdisciplinary Aspects and Sex Gender-Specific Differences)

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Abstract

We evaluated the sex-specific difference in response upon participation in an exercise program with respect to the risk of adverse clinical outcomes among patients with peripheral artery disease (PAD) and claudication. The records of 400 PAD patients were assessed between 2012 and 2015. Two hundred of them were addressed to a walking program prescribed at the hospital and executed at home at symptom-free walking speed (Ex), while the remaining 200 acted as a control group (Co). The number and date of deaths, all-cause hospitalizations, and amputations for a 7-year period were collected from the regional registry. At baseline, no differences were observed (M_EXn = 138; F_EXn = 62; M_COn = 149; F_COn = 51). The 7-year survival rate was significantly higher in F_EX (90%) than in M_EX (82% hazard ratio, HR: 0.542 95% CI 0.331–0.885), F_CO (45%, HR: 0.164 95% CI 0.088–0.305), and M_CO (44%; HR: 0.157 95% CI 0.096–0.256). A significantly lower rate of hospitalization (p < 0.001) and amputations (p = 0.016) was observed for the Ex group compared to the Co group, without differences by sex. In conclusion, in PAD patients, active participation in a home-based pain-free exercise program was associated with a lower rate of death and better long-term clinical outcomes, particularly among women.

Keywords: exercise; intermittent claudication; peripheral arterial disease; peripheral vascular diseases; walking; women; sex difference

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MDPI and ACS Style

Lamberti, N.; Traina, L.; Savriè, C.; Tsolaki, E.; Rinaldo, N.; Straudi, S.; Guerzoni, F.; Napoli, N.; Manfredini, R.; Gasbarro, V.; et al. Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study. J. Pers. Med. 2023, 13, 636. https://doi.org/10.3390/jpm13040636

AMA Style

Lamberti N, Traina L, Savriè C, Tsolaki E, Rinaldo N, Straudi S, Guerzoni F, Napoli N, Manfredini R, Gasbarro V, et al. Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study. Journal of Personalized Medicine. 2023; 13(4):636. https://doi.org/10.3390/jpm13040636

Chicago/Turabian Style

Lamberti, Nicola, Luca Traina, Caterina Savriè, Elpiniki Tsolaki, Natascia Rinaldo, Sofia Straudi, Franco Guerzoni, Nicola Napoli, Roberto Manfredini, Vincenzo Gasbarro, and et al. 2023. "Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study" Journal of Personalized Medicine 13, no. 4: 636. https://doi.org/10.3390/jpm13040636

APA Style

Lamberti, N., Traina, L., Savriè, C., Tsolaki, E., Rinaldo, N., Straudi, S., Guerzoni, F., Napoli, N., Manfredini, R., Gasbarro, V., & Manfredini, F. (2023). Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study. Journal of Personalized Medicine, 13(4), 636. https://doi.org/10.3390/jpm13040636

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Lower All-Cause Mortality Risk in Females and Males with Peripheral Artery Disease following Pain-Free Home-Based Exercise: A 7-Year Observational Study

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