Next Article in Journal
Introducing the “SIMline”—A Simulation Course in the Management of Severe Burns as a Tool in Undergraduate Medical Education
Next Article in Special Issue
Alterations in Retinal Vessel Diameters in Patients with Retinal Vein Occlusion before and after Treatment with Intravitreal Ranibizumab
Previous Article in Journal
Positive Clinical Outcomes for Severe Reported Pain Using Robust Non-Addictive Home Electrotherapy—A Case-Series
Previous Article in Special Issue
Machine Learning-Based Automated Detection and Quantification of Geographic Atrophy and Hypertransmission Defects Using Spectral Domain Optical Coherence Tomography
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JPM
Volume 13
Issue 2
10.3390/jpm13020337
jpm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Atypical Foveal Hypoplasia in Best Disease

by
Emmanuelle Moret
1,
Raphaël Lejoyeux
1,*,
Sophie Bonnin
1,
Georges Azar
1,
Jessica Guillaume
2,
Chloé Le Cossec
2,
Justine Lafolie
1,
Anne-Sophie Alonso
1,
Catherine Favard
3,
Isabelle Meunier
4,
Vivien Vasseur
1 and
Martine Mauget-Faÿsse
1
1
Plateforme d’Investigation Clinique, Hôpital Fondation Adolphe de Rothschild, 75019 Paris, France
2
Unité de Recherche Clinique, Hôpital Fondation Adolphe de Rothschild, 75019 Paris, France
3
Centre Ophtalmologique de l’Odéon, 113 Boulevard Saint Germain, 75006 Paris, France
4
CHU Gui de Chauliac, 80 Avenue Augustin Fliche, 34090 Montpellier, France
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2023, 13(2), 337; https://doi.org/10.3390/jpm13020337
Submission received: 22 November 2022 / Revised: 6 February 2023 / Accepted: 7 February 2023 / Published: 15 February 2023
(This article belongs to the Special Issue Precision Medicine for Retinal Disease)
Browse Figures
Review Reports Versions Notes

Abstract

Purpose: To determine the prevalence and characteristics of foveal hypoplasia (also called fovea plana) in patients with Best disease using spectral-domain (SD) optical coherence tomography (OCT) and OCT-angiography (OCT-A). Design: A retrospective observational study including patients diagnosed with Best disease. Subjects and Participants: Fifty-nine eyes of thirty-two patients (fifteen females (46.9%) and seventeen males (53.1%), p = 0.9) diagnosed with Best disease were included. Patients’ eyes were categorized into two groups: Eyes with a fovea plana appearance (‘FP group’) and eyes without fovea plana appearance (‘no FP group’), based on the foveal appearance on B-scan SD-OCT. Methods and Main Outcome Measures: Cross-sectional OCT images were assessed for the persistence of inner retinal layers (IRL) and OCT-A was analyzed for the presence of a foveal avascular zone (FAZ), the size of which was determined when applicable. Results: Overall, 16 eyes (27.1%) of 9 patients had a fovea plana appearance (‘FP group’) with the persistence of IRL, and 43 eyes (72.9%) of 23 patients did not have fovea plana appearance (‘no FP group’). Among FP eyes, OCT-A performed in 13 eyes showed bridging vessels through the FAZ in 100% of eyes with OCT-A. Using Thomas classification, 14 out of the 16 eyes with fovea plana (87.5%) had atypical foveal hypoplasia, and the 2 others (12.5%) had a grade 1b fovea plana. Conclusion: In our series, foveal hypoplasia was present in 27.1% of patients with Best disease. OCT-A showed bridging vessels through the FAZ in all eyes. These findings highlight the microvascular changes associated with Best disease, which can be an early sign of the disease in patients with a family history.
Keywords: Best disease; fovea plana; foveal hypoplasia; foveal avascular zone; OCT-A Best disease; fovea plana; foveal hypoplasia; foveal avascular zone; OCT-A

Share and Cite

MDPI and ACS Style

Moret, E.; Lejoyeux, R.; Bonnin, S.; Azar, G.; Guillaume, J.; Le Cossec, C.; Lafolie, J.; Alonso, A.-S.; Favard, C.; Meunier, I.; et al. Atypical Foveal Hypoplasia in Best Disease. J. Pers. Med. 2023, 13, 337. https://doi.org/10.3390/jpm13020337

AMA Style

Moret E, Lejoyeux R, Bonnin S, Azar G, Guillaume J, Le Cossec C, Lafolie J, Alonso A-S, Favard C, Meunier I, et al. Atypical Foveal Hypoplasia in Best Disease. Journal of Personalized Medicine. 2023; 13(2):337. https://doi.org/10.3390/jpm13020337

Chicago/Turabian Style

Moret, Emmanuelle, Raphaël Lejoyeux, Sophie Bonnin, Georges Azar, Jessica Guillaume, Chloé Le Cossec, Justine Lafolie, Anne-Sophie Alonso, Catherine Favard, Isabelle Meunier, and et al. 2023. "Atypical Foveal Hypoplasia in Best Disease" Journal of Personalized Medicine 13, no. 2: 337. https://doi.org/10.3390/jpm13020337

APA Style

Moret, E., Lejoyeux, R., Bonnin, S., Azar, G., Guillaume, J., Le Cossec, C., Lafolie, J., Alonso, A.-S., Favard, C., Meunier, I., Vasseur, V., & Mauget-Faÿsse, M. (2023). Atypical Foveal Hypoplasia in Best Disease. Journal of Personalized Medicine, 13(2), 337. https://doi.org/10.3390/jpm13020337

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop