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Article

Interferon-Inducible Protein-10 as a Marker to Detect Latent Tuberculosis Infection in Patients with Inflammatory Rheumatic Diseases

1
Department of Pulmonary Disease, University of Health Sciences Turkey, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, Istanbul 34020, Turkey
2
Department of Pulmonary Disease, Koc University Hospital, Istanbul 34010, Turkey
3
Department of Physical Medicine and Rehabilitation, Istanbul Physical Medicine and Rehabilitation Training Hospital, Istanbul 34186, Turkey
*
Author to whom correspondence should be addressed.
Academic Editors: Ioannis Pantazopoulos and Ourania S. Kotsiou
J. Pers. Med. 2022, 12(7), 1027; https://doi.org/10.3390/jpm12071027
Received: 31 May 2022 / Revised: 17 June 2022 / Accepted: 20 June 2022 / Published: 23 June 2022
(This article belongs to the Special Issue Respiratory and Critical Care)
It is important to identify cases of latent tuberculosis infection (LTBI) who are at risk for tuberculosis (TB) reactivation. We aimed to evaluate the performance of interferon (IFN)-gamma-inducible protein 10 (IP-10) as a marker to detect LTBI in patients with inflammatory rheumatic diseases (IRD). This study comprised 76 consecutive subjects with IRD. Patients with a history of TB or having active TB were excluded. In all patients, IP-10 level was measured and tuberculin skin test (TST) and QuantiFERON-TB Gold In-Tube test (QFT-GIT) were performed. Seventy patients with complete test results were analyzed. Twenty-one (30%) QFT-GIT-positive patients were defined as having LTBI. IP-10 yielded 2197 pg/mL cut-off point. At this cut-off point, IP-10 showed 89% specificity with a sensitivity of 91% (AUC: 0.950, 95% CI 0.906–0.994). TST, QFT-GIT, and IP-10 were positive in 77.1%, 30%, and 44.3% of the patients, respectively. Concordance among the results of TST, QFT-GIT, and IP-10 tests was evaluated. Agreement was poor between IP-10 and TST (58.6%, κ = 0.19), whereas it was good between QFT-GIT and IP-10 (84.3%, κ = 0.65). The results of the present study demonstrated that sensitivity and specificity of released IP-10 were as high as those of QFT-GIT in indicating LTBI in IRD patient group. View Full-Text
Keywords: latent tuberculosis; inflammatory rheumatoid disease; interferon-inducible protein-10 latent tuberculosis; inflammatory rheumatoid disease; interferon-inducible protein-10
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MDPI and ACS Style

Ortakoylu, M.G.; Bahadir, A.; Iliaz, S.; Soy Bugdayci, D.; Uysal, M.A.; PAKER, N.; Tural Onur, S. Interferon-Inducible Protein-10 as a Marker to Detect Latent Tuberculosis Infection in Patients with Inflammatory Rheumatic Diseases. J. Pers. Med. 2022, 12, 1027. https://doi.org/10.3390/jpm12071027

AMA Style

Ortakoylu MG, Bahadir A, Iliaz S, Soy Bugdayci D, Uysal MA, PAKER N, Tural Onur S. Interferon-Inducible Protein-10 as a Marker to Detect Latent Tuberculosis Infection in Patients with Inflammatory Rheumatic Diseases. Journal of Personalized Medicine. 2022; 12(7):1027. https://doi.org/10.3390/jpm12071027

Chicago/Turabian Style

Ortakoylu, Mediha G., Ayse Bahadir, Sinem Iliaz, Derya Soy Bugdayci, Mehmet A. Uysal, Nurdan PAKER, and Seda Tural Onur. 2022. "Interferon-Inducible Protein-10 as a Marker to Detect Latent Tuberculosis Infection in Patients with Inflammatory Rheumatic Diseases" Journal of Personalized Medicine 12, no. 7: 1027. https://doi.org/10.3390/jpm12071027

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