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Article

Enhanced Risk of Osteoporotic Fracture in Patients with Sarcopenia: A National Population-Based Study in Taiwan

by 1,2,3,4,†, 5,6,7,†, 8,9,†, 10,†, 9,11, 10,12,13, 11, 9,11,*,†, 1, 7,14 and 15
1
Biomedica Corporation, New Taipei 23146, Taiwan
2
Ph.D. Program for Aging, China Medical University, Taichung 40402, Taiwan
3
Institute of Population Health Sciences, National Health Research Institutes, Miaoli 35053, Taiwan
4
Department of Electrical and Computer Engineering, Institute of Electrical Control Engineering, National Yang Ming Chiao Tung University, Hsinchu 30010, Taiwan
5
Department of Computer Science & Information Engineering, Asia University, Taichung 41354, Taiwan
6
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
7
Center for Precision Medicine Research, Asia University, Taichung 41354, Taiwan
8
Department of Orthopedics, Taipei Medical University Hospital, Taipei 11031, Taiwan
9
Department of Orthopedics, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
10
Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
11
Department of Orthopedics, Wan Fang Hospital, Taipei Medical University, Taipei 11696, Taiwan
12
Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
13
Department of Geriatric Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
14
Department of Bioinformatics and Medical Engineering, Asia University, Taichung 41354, Taiwan
15
Graduate Institute of Biomedical Science, China Medical University, Taichung 40402, Taiwan
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Academic Editor: Alessio Molfino
J. Pers. Med. 2022, 12(5), 791; https://doi.org/10.3390/jpm12050791 (registering DOI)
Received: 6 April 2022 / Revised: 8 May 2022 / Accepted: 9 May 2022 / Published: 13 May 2022
(This article belongs to the Section Epidemiology)
Sarcopenia is a progressive and generalized skeletal muscle disorder associated with poor health outcomes in older adults. However, its association with the risk of fracture risk is yet to be clarified. Therefore, this study aimed to assess the incidence and consequence of osteoporosis-related fractures among patients with sarcopenia in Taiwan. A retrospective, population-based study on 616 patients with sarcopenia, aged >40 years, and 1232 individuals without sarcopenia was conducted to evaluate claims data from Taiwan’s National Health Insurance Research Database collected in the period January 2000–December 2013. The incidence rate of osteoporosis-related fracture was 18.13 and 14.61 per 1000 person years in the patients with sarcopenia and comparison cohort, respectively. Patients with sarcopenia had a greater osteoporotic fracture risk (adjusted hazard ratio [HR] 2.11; 95% confidence interval [CI] 1.47–3.04) after correcting for possible confounding. Additionally, females showed statistically significant correlations of sarcopenia with osteoporosis-related fracture risk (HR 1.53; CI 0.83–2.8 for males and HR 2.40, CI 1.51–3.81 for females). During this retrospective study on the fracture risk in Taiwan, an adverse impact of sarcopenia was observed, which substantiates the need to work toward sarcopenia prevention and interventions to reverse fracture susceptibility in patients with sarcopenia. View Full-Text
Keywords: sarcopenia; fracture; osteoporosis; incidence; nationwide population-based study sarcopenia; fracture; osteoporosis; incidence; nationwide population-based study
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MDPI and ACS Style

Zhang, H.-W.; Tsai, Z.-R.; Chen, K.-T.; Hsu, S.-L.; Kuo, Y.-J.; Lin, Y.-C.; Huang, S.-W.; Chen, Y.-P.; Peng, H.-C.; Tsai, J.J.P.; Hsu, C.-Y. Enhanced Risk of Osteoporotic Fracture in Patients with Sarcopenia: A National Population-Based Study in Taiwan. J. Pers. Med. 2022, 12, 791. https://doi.org/10.3390/jpm12050791

AMA Style

Zhang H-W, Tsai Z-R, Chen K-T, Hsu S-L, Kuo Y-J, Lin Y-C, Huang S-W, Chen Y-P, Peng H-C, Tsai JJP, Hsu C-Y. Enhanced Risk of Osteoporotic Fracture in Patients with Sarcopenia: A National Population-Based Study in Taiwan. Journal of Personalized Medicine. 2022; 12(5):791. https://doi.org/10.3390/jpm12050791

Chicago/Turabian Style

Zhang, Han-Wei, Zhi-Ren Tsai, Ko-Ta Chen, Sheng-Lun Hsu, Yi-Jie Kuo, Ying-Chin Lin, Shu-Wei Huang, Yu-Pin Chen, Hsiao-Ching Peng, Jeffrey J.P. Tsai, and Chun-Yi Hsu. 2022. "Enhanced Risk of Osteoporotic Fracture in Patients with Sarcopenia: A National Population-Based Study in Taiwan" Journal of Personalized Medicine 12, no. 5: 791. https://doi.org/10.3390/jpm12050791

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