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Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures

1
Division of Aging and Carcinogenesis, Research Team for Geriatric Pathology, Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
2
Research Team for Geriatric Medicine (Vascular Medicine), Tokyo Metropolitan Institute of Gerontology, Tokyo 173-0015, Japan
3
Department of Pathology, Tokyo Metropolitan Hospital and Institute of Gerontology, Tokyo 173-0015, Japan
*
Author to whom correspondence should be addressed.
Academic Editor: Johannes Mosbacher
J. Pers. Med. 2022, 12(5), 746; https://doi.org/10.3390/jpm12050746
Received: 22 March 2022 / Revised: 1 May 2022 / Accepted: 2 May 2022 / Published: 4 May 2022
Pancreatic ductal adenocarcinoma (PDAC) is an intractable cancer that is difficult to diagnose early, and there is no cure other than surgery. PDAC is classified as an adenocarcinoma that has limited effective anticancer drug and molecular-targeted therapies compared to adenocarcinoma found in other organs. A large number of cancer cell lines have been established from patients with PDAC that have different genetic abnormalities, including four driver genes; however, little is known about the differences in biological behaviors among these cell lines. Recent studies have shown that PDAC cell lines can be divided into epithelial and mesenchymal cell lines. In 3D cultures, morphological and functional differences between epithelial and mesenchymal PDAC cell lines were observed as well as the drug effects of different anticancer drugs. These effects included gemcitabine causing an increased growth inhibition of epithelial PDAC cells, while nab-paclitaxel caused greater mesenchymal PDAC cell inhibition. Thus, examining the characteristics of epithelial or mesenchymal PDAC cells with stromal cells using a 3D co-culture may lead to the development of new anticancer drugs. View Full-Text
Keywords: pancreatic cancer; pancreatic ductal adenocarcinoma; cell line; two-dimensional culture; three-dimensional culture pancreatic cancer; pancreatic ductal adenocarcinoma; cell line; two-dimensional culture; three-dimensional culture
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MDPI and ACS Style

Shichi, Y.; Gomi, F.; Sasaki, N.; Nonaka, K.; Arai, T.; Ishiwata, T. Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures. J. Pers. Med. 2022, 12, 746. https://doi.org/10.3390/jpm12050746

AMA Style

Shichi Y, Gomi F, Sasaki N, Nonaka K, Arai T, Ishiwata T. Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures. Journal of Personalized Medicine. 2022; 12(5):746. https://doi.org/10.3390/jpm12050746

Chicago/Turabian Style

Shichi, Yuuki, Fujiya Gomi, Norihiko Sasaki, Keisuke Nonaka, Tomio Arai, and Toshiyuki Ishiwata. 2022. "Epithelial and Mesenchymal Features of Pancreatic Ductal Adenocarcinoma Cell Lines in Two- and Three-Dimensional Cultures" Journal of Personalized Medicine 12, no. 5: 746. https://doi.org/10.3390/jpm12050746

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