Diversity of Circulating NKT Cells in Defense against Carbapenem-Resistant Klebsiella Pneumoniae Infection
Abstract
:1. Introduction
2. Materials and Methods
2.1. Clinical Samples Collection
2.2. Single-Cell RNA Sequencing
2.3. Single-Cell Data Processing
2.4. RNA Velocity Analyses
2.5. Time Dependent Transcriptional Analysis
2.6. Cell–Cell Communication Analysis
2.7. Statistical Analysis
3. Results
3.1. NK and NKT Subset Distribution in Patients during CRKP Infection
3.2. Transcriptional Alterations of NK and NKT Subsets during CRKP Infection
3.3. The Regulatory Effect of NKT on NK Function during CRKP Infection
4. Discussion
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Wang, Y.; Zang, F.; Ye, X.; Li, Z.; Zhu, W.; Cao, X.; Cai, X.; Ma, X.; Xu, L.; Zhang, Y.; et al. Diversity of Circulating NKT Cells in Defense against Carbapenem-Resistant Klebsiella Pneumoniae Infection. J. Pers. Med. 2022, 12, 2025. https://doi.org/10.3390/jpm12122025
Wang Y, Zang F, Ye X, Li Z, Zhu W, Cao X, Cai X, Ma X, Xu L, Zhang Y, et al. Diversity of Circulating NKT Cells in Defense against Carbapenem-Resistant Klebsiella Pneumoniae Infection. Journal of Personalized Medicine. 2022; 12(12):2025. https://doi.org/10.3390/jpm12122025
Chicago/Turabian StyleWang, Yidi, Feng Zang, Xiangyu Ye, Zhanjie Li, Wenhao Zhu, Xiaoxiao Cao, Xuehong Cai, Xinyan Ma, Lei Xu, Yongxiang Zhang, and et al. 2022. "Diversity of Circulating NKT Cells in Defense against Carbapenem-Resistant Klebsiella Pneumoniae Infection" Journal of Personalized Medicine 12, no. 12: 2025. https://doi.org/10.3390/jpm12122025