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Volume 12
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10.3390/jpm12101616
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Review

Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review

by
Bruno Sergi
1,2,
Stefano Settimi
1,2,*,
Gaia Federici
3,
Costanza Galloni
3,
Carla Cantaffa
3,
Eugenio De Corso
2 and
Daniela Lucidi
3
1
Department of Head, Neck and Sensory Organs, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
2
Unit of Otorhinolaryngology-Head and Neck Surgery, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy
3
Department of Otolaryngology-Head and Neck Surgery, University Hospital of Modena, University of Modena and Reggio Emilia, 41125 Modena, Italy
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2022, 12(10), 1616; https://doi.org/10.3390/jpm12101616
Submission received: 23 July 2022 / Revised: 21 September 2022 / Accepted: 25 September 2022 / Published: 30 September 2022
(This article belongs to the Section Personalized Therapy in Clinical Medicine)
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Abstract

Management of vestibular schwannoma (VS) is a complex process aimed at identifying a clinical indication for fractionated stereotactic radiotherapy (sRT) or microsurgical resection or wait and scan (WS). The aim of the review was to clarify which patient and tumor parameters may lead to different therapeutic choices, with a view to a personalized VS approach. A systematic review according to Preferred Reporting Items for Systematic Review and Meta-Analysis criteria was conducted between February and March 2022. The authors defined six parameters that seemed to influence decision-making in VS management: 1-incidental VS; 2-tumor size; 3-tumor regrowth after sRT; 4-subtotal resection; 5-patients’ age; 6-symptoms. The initial search yielded 3532 articles, and finally, 812 articles were included. Through a qualitative synthesis of the included studies, management strategies were evaluated and discussed. An individualized proposal of procedures is preferable as compared to a single gold-standard approach in VS decision-making. The most significant factors that need to be considered when dealing with a VS diagnosis are age, tumor size and hearing preservation issues.
Keywords: vestibular schwannoma; acoustic neuroma; translabyrinthine; retrosigmoid; middle cranial fossa; stereotactic radiotherapy; radiosurgery; gamma knife; quality of life vestibular schwannoma; acoustic neuroma; translabyrinthine; retrosigmoid; middle cranial fossa; stereotactic radiotherapy; radiosurgery; gamma knife; quality of life

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MDPI and ACS Style

Sergi, B.; Settimi, S.; Federici, G.; Galloni, C.; Cantaffa, C.; De Corso, E.; Lucidi, D. Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review. J. Pers. Med. 2022, 12, 1616. https://doi.org/10.3390/jpm12101616

AMA Style

Sergi B, Settimi S, Federici G, Galloni C, Cantaffa C, De Corso E, Lucidi D. Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review. Journal of Personalized Medicine. 2022; 12(10):1616. https://doi.org/10.3390/jpm12101616

Chicago/Turabian Style

Sergi, Bruno, Stefano Settimi, Gaia Federici, Costanza Galloni, Carla Cantaffa, Eugenio De Corso, and Daniela Lucidi. 2022. "Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review" Journal of Personalized Medicine 12, no. 10: 1616. https://doi.org/10.3390/jpm12101616

APA Style

Sergi, B., Settimi, S., Federici, G., Galloni, C., Cantaffa, C., De Corso, E., & Lucidi, D. (2022). Factors Influencing Personalized Management of Vestibular Schwannoma: A Systematic Review. Journal of Personalized Medicine, 12(10), 1616. https://doi.org/10.3390/jpm12101616

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