Next Article in Journal
GPR30 Activation by 17β-Estradiol Promotes p62 Phosphorylation and Increases Estrogen Receptor α Protein Expression by Inducing Its Release from a Complex Formed with KEAP1
Previous Article in Journal
Current Challenges in Deciphering Sutton Nevi—Literature Review and Personal Experience
Previous Article in Special Issue
Efficient Genetic Safety Switches for Future Application of iPSC-Derived Cell Transplants
Review

Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism

1
Department of Cell Biology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, 30-387 Krakow, Poland
2
Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, Poland
*
Author to whom correspondence should be addressed.
Academic Editor: Giorgio Malpeli
J. Pers. Med. 2021, 11(9), 905; https://doi.org/10.3390/jpm11090905
Received: 16 July 2021 / Revised: 30 August 2021 / Accepted: 8 September 2021 / Published: 10 September 2021
Human-induced pluripotent stem cells (hiPSCs) offer numerous possibilities in science and medicine, particularly when combined with precise genome editing methods. hiPSCs are artificially generated equivalents of human embryonic stem cells (hESCs), which possess an unlimited ability to self-renew and the potential to differentiate into any cell type of the human body. Importantly, generating patient-specific hiPSCs enables personalized drug testing or autologous cell therapy upon differentiation into a desired cell line. However, to ensure the highest standard of hiPSC-based biomedical products, their safety and reliability need to be proved. One of the key factors influencing human pluripotent stem cell (hPSC) characteristics and function is oxygen concentration in their microenvironment. In recent years, emerging data have pointed toward the beneficial effect of low oxygen pressure (hypoxia) on both hiPSCs and hESCs. In this review, we examine the state-of-the-art research on the oxygen impact on hiPSC functions and activity with an emphasis on their niche, metabolic state, reprogramming efficiency, and differentiation potential. We also discuss the similarities and differences between PSCs and cancer stem cells (CSCs) with respect to the role of oxygen in both cell types. View Full-Text
Keywords: oxygen; hypoxia; hypoxia-inducible factors; induced pluripotent stem cells; metabolism; cancer stem cells oxygen; hypoxia; hypoxia-inducible factors; induced pluripotent stem cells; metabolism; cancer stem cells
Show Figures

Graphical abstract

MDPI and ACS Style

Nit, K.; Tyszka-Czochara, M.; Bobis-Wozowicz, S. Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism. J. Pers. Med. 2021, 11, 905. https://doi.org/10.3390/jpm11090905

AMA Style

Nit K, Tyszka-Czochara M, Bobis-Wozowicz S. Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism. Journal of Personalized Medicine. 2021; 11(9):905. https://doi.org/10.3390/jpm11090905

Chicago/Turabian Style

Nit, Kinga, Malgorzata Tyszka-Czochara, and Sylwia Bobis-Wozowicz. 2021. "Oxygen as a Master Regulator of Human Pluripotent Stem Cell Function and Metabolism" Journal of Personalized Medicine 11, no. 9: 905. https://doi.org/10.3390/jpm11090905

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop