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Article

Pain Improvement in Parkinson’s Disease Patients Treated with Safinamide: Results from the SAFINONMOTOR Study

1
Department of Neurology, CHUAC, Complejo Hospitalario Universitario de A Coruña, 15006 A Coruña, Spain
2
Department of Neurology, CHUO, Complejo Hospitalario Universitario de Ourense, 32005 Ourense, Spain
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Department of Neurology, CHUVI, Complejo Hospitalario Universitario de Vigo, 36213 Vigo, Spain
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Hospital de Povisa, 36211 Vigo, Spain
5
Department of Neurology, CHOP, Complejo Hospitalario Universitario de Pontevedra, 36002 Pontevedra, Spain
*
Author to whom correspondence should be addressed.
Academic Editors: Chiara Villa and Felix Javier Jiménez Jiménez
J. Pers. Med. 2021, 11(8), 798; https://doi.org/10.3390/jpm11080798
Received: 8 July 2021 / Revised: 30 July 2021 / Accepted: 14 August 2021 / Published: 16 August 2021
(This article belongs to the Special Issue Advances in the Therapeutics of Neurological Diseases)
Background and objective: Pain is a frequent and disabling symptom in Parkinson’s disease (PD) patients. Our aim was to analyze the effectiveness of safinamide on pain in PD patients from the SAFINONMOTOR (an open-label study of the effectiveness of SAFInamide on NON-MOTOR symptoms in Parkinson´s disease patients) study. Material and Methods: SAFINONMOTOR is a prospective open-label single-arm study conducted in five centers from Spain. In this analysis, a secondary objective of the study, the score in the KPPS (King´s Parkinson´s Disease Pain Scale) at V1 (baseline) and V4 (6 months ± 1 month) were compared. Wilcoxon´s rank sum test was performed to test the changes from V1 to V4. Results: Forty-four (88%) out of 50 PD patients (age 68.5 ± 9.12 years; 58% women; 6.4 ± 5.1 years from diagnosis) completed the study. The KPPS total score was reduced by 43.6% (from 40.04 ± 36.18 in V1 to 22.60 ± 21.42 in V4; p < 0.0001). By domains, improvement was observed in musculoskeletal (−35.9%; p = 0.009), fluctuation-related (−51.7%; p = 0.020), nocturnal (−46.1%; p = 0.001), discoloration and/or edema/swelling (−50.4%; p = 0.009) and radicular pain (−40.1%; p = 0.048). A total of 21 adverse events in 11 patients (22%) were reported, five being severe, but not related to safinamide. Conclusion: Safinamide is well tolerated and improves pain in PD patients at 6 months. Future studies are necessary to analyze the possible beneficial effect of safinamide on pain in PD patients. View Full-Text
Keywords: effectiveness; non-motor symptoms; pain; Parkinson’s disease; safinamide effectiveness; non-motor symptoms; pain; Parkinson’s disease; safinamide
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MDPI and ACS Style

Santos García, D.; Yáñez Baña, R.; Labandeira Guerra, C.; Cimas Hernando, M.I.; Cabo López, I.; Paz González, J.M.; Alonso Losada, M.G.; Gonzalez Palmás, M.J.; Cores Bartolomé, C.; Martínez Miró, C. Pain Improvement in Parkinson’s Disease Patients Treated with Safinamide: Results from the SAFINONMOTOR Study. J. Pers. Med. 2021, 11, 798. https://doi.org/10.3390/jpm11080798

AMA Style

Santos García D, Yáñez Baña R, Labandeira Guerra C, Cimas Hernando MI, Cabo López I, Paz González JM, Alonso Losada MG, Gonzalez Palmás MJ, Cores Bartolomé C, Martínez Miró C. Pain Improvement in Parkinson’s Disease Patients Treated with Safinamide: Results from the SAFINONMOTOR Study. Journal of Personalized Medicine. 2021; 11(8):798. https://doi.org/10.3390/jpm11080798

Chicago/Turabian Style

Santos García, Diego, Rosa Yáñez Baña, Carmen Labandeira Guerra, Maria I. Cimas Hernando, Iria Cabo López, Jose M. Paz González, Maria G. Alonso Losada, Maria J. Gonzalez Palmás, Carlos Cores Bartolomé, and Cristina Martínez Miró. 2021. "Pain Improvement in Parkinson’s Disease Patients Treated with Safinamide: Results from the SAFINONMOTOR Study" Journal of Personalized Medicine 11, no. 8: 798. https://doi.org/10.3390/jpm11080798

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