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Review

Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System

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GT MP Covid-19. SGIDIS, Consejería de Salud y Familias, Junta de Andalucía, Spain
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Área de Bioinformática, Fundación progreso y Salud, Junta de Andalucía, 41013 Sevilla, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), 28029 Madrid, Spain
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Instituto de Biomedicina de Sevilla (HUVR/HUVM/CSIC/US), 41013 Sevilla, Spain
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Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), 28029 Madrid, Spain
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Servicio de Microbiología, Hospital Universitario San Cecilio, 18016 Granada, Spain
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Instituto de Investigación Biosanitaria IBS, 18012 Granada, Spain
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Dirección General de Salud Pública, Consejería de Salud y Familias, Junta de Andalucía, Spain
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Servicio de Farmacia, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
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Hospital Universitario de Valme, 41014 Sevilla, Spain
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Servicio de Medicina Interna, Hospital Universitario Reina Sofía, 14004 Córdoba, Spain
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Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), 14004 Córdoba, Spain
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Departamento de Ciencias Médicas y Quirúrgicas, Universidad de Córdoba, 14071 Córdoba, Spain
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Unidad Clínica de Enfermedades Infecciosas y Microbiología, Hospital Universitario Virgen Macarena, 41009 Sevilla, Spain
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Departamento de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain
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Departamento de Cirugía, Universidad de Sevilla, 41009 Sevilla, Spain
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Servicio de Cirugía General y Digestiva, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
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Departamento de Bioquímica, Universidad de Córdoba, 14071 Córdoba, Spain
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Secretaría General de Investigación, Desarrollo e Innovación en Salud, Consejería de Salud y Familias de la Junta de Andalucía, 41020 Sevilla, Spain
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Servicio de Aparato Digestivo, Hospital Universitario Virgen del Rocío, 41013 Sevilla, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Rutger A. Middelburg
J. Pers. Med. 2021, 11(6), 475; https://doi.org/10.3390/jpm11060475
Received: 22 April 2021 / Revised: 19 May 2021 / Accepted: 21 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Personalized Medicine in Epidemics)
The COVID-19 pandemic represents an unprecedented opportunity to exploit the advantages of personalized medicine for the prevention, diagnosis, treatment, surveillance and management of a new challenge in public health. COVID-19 infection is highly variable, ranging from asymptomatic infections to severe, life-threatening manifestations. Personalized medicine can play a key role in elucidating individual susceptibility to the infection as well as inter-individual variability in clinical course, prognosis and response to treatment. Integrating personalized medicine into clinical practice can also transform health care by enabling the design of preventive and therapeutic strategies tailored to individual profiles, improving the detection of outbreaks or defining transmission patterns at an increasingly local level. SARS-CoV2 genome sequencing, together with the assessment of specific patient genetic variants, will support clinical decision-makers and ultimately better ways to fight this disease. Additionally, it would facilitate a better stratification and selection of patients for clinical trials, thus increasing the likelihood of obtaining positive results. Lastly, defining a national strategy to implement in clinical practice all available tools of personalized medicine in COVID-19 could be challenging but linked to a positive transformation of the health care system. In this review, we provide an update of the achievements, promises, and challenges of personalized medicine in the fight against COVID-19 from susceptibility to natural history and response to therapy, as well as from surveillance to control measures and vaccination. We also discuss strategies to facilitate the adoption of this new paradigm for medical and public health measures during and after the pandemic in health care systems. View Full-Text
Keywords: personalized medicine; precision medicine; Covid-19; SARS CoV2; epidemiology; host genetics; viral genome personalized medicine; precision medicine; Covid-19; SARS CoV2; epidemiology; host genetics; viral genome
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Graphical abstract

MDPI and ACS Style

Dopazo, J.; Maya-Miles, D.; García, F.; Lorusso, N.; Calleja, M.Á.; Pareja, M.J.; López-Miranda, J.; Rodríguez-Baño, J.; Padillo, J.; Túnez, I.; Romero-Gómez, M. Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System. J. Pers. Med. 2021, 11, 475. https://doi.org/10.3390/jpm11060475

AMA Style

Dopazo J, Maya-Miles D, García F, Lorusso N, Calleja MÁ, Pareja MJ, López-Miranda J, Rodríguez-Baño J, Padillo J, Túnez I, Romero-Gómez M. Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System. Journal of Personalized Medicine. 2021; 11(6):475. https://doi.org/10.3390/jpm11060475

Chicago/Turabian Style

Dopazo, Joaquín, Douglas Maya-Miles, Federico García, Nicola Lorusso, Miguel Á. Calleja, María J. Pareja, José López-Miranda, Jesús Rodríguez-Baño, Javier Padillo, Isaac Túnez, and Manuel Romero-Gómez. 2021. "Implementing Personalized Medicine in COVID-19 in Andalusia: An Opportunity to Transform the Healthcare System" Journal of Personalized Medicine 11, no. 6: 475. https://doi.org/10.3390/jpm11060475

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