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Article

The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder

1
Institute of Higher Education and Research in Healthcare (IUFRS), University of Lausanne, 1010 Lausanne, Switzerland
2
Department of Clinical Psychology and Psychotherapy, University of Zurich, 8050 Zurich, Switzerland
3
Clinical Child Psychology & Biological Psychology, University of Fribourg, 1701 Fribourg, Switzerland
4
Neonatology Service, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland
*
Author to whom correspondence should be addressed.
Joint last authors.
Academic Editors: Antonio Armario, Roser Nadal and Javier Labad
J. Pers. Med. 2021, 11(6), 472; https://doi.org/10.3390/jpm11060472
Received: 12 April 2021 / Revised: 21 May 2021 / Accepted: 24 May 2021 / Published: 26 May 2021
(This article belongs to the Special Issue Neurobiology and Individual Differences in Stress)
Stress reactivity is typically investigated in laboratory settings, which is inadequate for mothers in maternity settings. This study aimed at validating the Lausanne Infant Crying Stress Paradigm (LICSP) as a new psychosocial stress paradigm eliciting psychophysiological stress reactivity in early postpartum mothers (n = 52) and to compare stress reactivity in women at low (n = 28) vs. high risk (n = 24) of childbirth-related posttraumatic stress disorder (CB-PTSD). Stress reactivity was assessed at pre-, peri-, and post-stress levels through salivary cortisol, heart rate variability (high-frequency (HF) power, low-frequency (LF) power, and LF/HF ratio), and perceived stress via a visual analog scale. Significant time effects were observed for all stress reactivity outcomes in the total sample (all p < 0.01). When adjusting for perceived life threat for the infant during childbirth, high-risk mothers reported higher perceived stress (p < 0.001, d = 0.91) and had lower salivary cortisol release (p = 0.023, d = 0.53), lower LF/HF ratio (p < 0.001, d = 0.93), and marginally higher HF power (p = 0.07, d = 0.53) than low-risk women. In conclusion, the LICSP induces subjective stress and autonomic nervous system (ANS) reactivity in maternity settings. High-risk mothers showed higher perceived stress and altered ANS and hypothalamic–pituitary–adrenal reactivity when adjusting for infant life threat. Ultimately, the LICSP could stimulate (CB-)PTSD research. View Full-Text
Keywords: PTSD; cortisol; heart rate variability; stress reactivity; childbirth; TSST; postpartum; women; mothers; perceived stress PTSD; cortisol; heart rate variability; stress reactivity; childbirth; TSST; postpartum; women; mothers; perceived stress
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MDPI and ACS Style

Sandoz, V.; Stuijfzand, S.; Lacroix, A.; Deforges, C.; Quillet Diop, M.; Ehlert, U.; Rubo, M.; Messerli-Bürgy, N.; Horsch, A. The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder. J. Pers. Med. 2021, 11, 472. https://doi.org/10.3390/jpm11060472

AMA Style

Sandoz V, Stuijfzand S, Lacroix A, Deforges C, Quillet Diop M, Ehlert U, Rubo M, Messerli-Bürgy N, Horsch A. The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder. Journal of Personalized Medicine. 2021; 11(6):472. https://doi.org/10.3390/jpm11060472

Chicago/Turabian Style

Sandoz, Vania, Suzannah Stuijfzand, Alain Lacroix, Camille Deforges, Magali Quillet Diop, Ulrike Ehlert, Marius Rubo, Nadine Messerli-Bürgy, and Antje Horsch. 2021. "The Lausanne Infant Crying Stress Paradigm: Validation of an Early Postpartum Stress Paradigm with Women at Low vs. High Risk of Childbirth-Related Posttraumatic Stress Disorder" Journal of Personalized Medicine 11, no. 6: 472. https://doi.org/10.3390/jpm11060472

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