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Open AccessArticle

Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants

Department of Neuropsychiatry, Graduate School of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Academic Editor: Sabata Martino
J. Pers. Med. 2021, 11(2), 68; https://doi.org/10.3390/jpm11020068
Received: 31 December 2020 / Revised: 20 January 2021 / Accepted: 22 January 2021 / Published: 24 January 2021
Background: The present study aimed to examine the acute neurophysiological effects of 1Hz transcranial magnetic stimulation (TMS) administered to the right dorsolateral prefrontal cortex (DLPFC) in healthy participants. Methods: TMS combined with simultaneous electroencephalography (EEG) recording was conducted for 21 healthy participants. For the right DLPFC, 1Hz-TMS (100 pulses/block × 17 sessions) was applied in the resting-state, while for the left DLPFC, 1Hz-TMS (100 pulses/block × 2 sessions) was administered during the verbal fluency tasks (VFTs). For TMS-EEG data, independent component analysis (ICA) was applied to extract TMS-evoked EEG potentials to calculate TMS-related power as well as TMS-related coherence from the F4 and F3 electrode sites during the resting-state and VFTs. Results: TMS-related power was significantly increased in alpha, beta, and gamma bands by 1Hz-TMS at the stimulation site during the resting-state, while TMS-related power was significantly increased in alpha and beta bands but not in the gamma band during the VFTs. On the other hand, TMS-related coherence in alpha and beta bands significantly increased but not in gamma band by 1Hz-TMS that was administered to the right DLPFC in resting-state, whereas there were no significant changes in coherence for all frequency bands by 1Hz-TMS that applied to the left DLPFC during the VFTs. Conclusions: Collectively, 1Hz-repetitive TMS (rTMS) to the right DLPFC may rapidly neuromodulate EEG activity, which might be associated with a therapeutic mechanism for depression. View Full-Text
Keywords: dorsolateral prefrontal cortex (DLPFC); electroencephalography (EEG); neuromodulation; neurophysiology; transcranial magnetic stimulation (TMS); TMS-EEG; TMS-evoked potential (TEP); TMS-related coherence; TMS-related power dorsolateral prefrontal cortex (DLPFC); electroencephalography (EEG); neuromodulation; neurophysiology; transcranial magnetic stimulation (TMS); TMS-EEG; TMS-evoked potential (TEP); TMS-related coherence; TMS-related power
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MDPI and ACS Style

Noda, Y. Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants. J. Pers. Med. 2021, 11, 68. https://doi.org/10.3390/jpm11020068

AMA Style

Noda Y. Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants. Journal of Personalized Medicine. 2021; 11(2):68. https://doi.org/10.3390/jpm11020068

Chicago/Turabian Style

Noda, Yoshihiro. 2021. "Potential Neurophysiological Mechanisms of 1Hz-TMS to the Right Prefrontal Cortex for Depression: An Exploratory TMS-EEG Study in Healthy Participants" J. Pers. Med. 11, no. 2: 68. https://doi.org/10.3390/jpm11020068

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