Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients
Abstract
:Highlights
- The single-pulse transcranial magnetic stimulation (TMS) (spTMS) allows probing and visualization of the spatiotemporal characteristics of each young (YNG), older (OLD), and schizophrenia (SCZ) group.
- Different TMS-evoked potential (TEP) characteristics induced by spTMS were observed in the OLD and SCZ compared with YNG.
- Specifically, changes in P30 and N45 deflections of TEPs by spTMS were important in classifying these groups across the motor cortex (M1) and dorsolateral prefrontal cortex (DLPFC).
1. Introduction
2. Materials and Methods
2.1. Participants
2.2. TMS Procedure
2.3. EEG Recording and Pre-Processing
2.4. EEG Signal Processing
2.5. Single-Pulses TMS-Evoked Potential (TEP) Analyses
2.6. Statistical Analyses
3. Results
3.1. TEP Amplitude Differences between the YNG, OLD, and SCZ Groups
3.2. Predictive Factors to Classify the Groups Based on the Multiple Regression Analysis
3.3. Latency Differences for Each TEP between the YNG, OLD, and SCZ Groups
3.4. Latency Differences between the Stimulated ROI and Other ROIs within the YNG, OLD, and SCZ Groups
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
Abbreviations
SpTMS | single-pulse transcranial magnetic stimulation |
M1 | primary motor cortex |
DLPFC | dorsolateral prefrontal cortex |
TEP | TMS-evoked potential |
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Noda, Y.; Barr, M.S.; Zomorrodi, R.; Cash, R.F.H.; Lioumis, P.; Chen, R.; Daskalakis, Z.J.; Blumberger, D.M. Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients. J. Pers. Med. 2021, 11, 54. https://doi.org/10.3390/jpm11010054
Noda Y, Barr MS, Zomorrodi R, Cash RFH, Lioumis P, Chen R, Daskalakis ZJ, Blumberger DM. Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients. Journal of Personalized Medicine. 2021; 11(1):54. https://doi.org/10.3390/jpm11010054
Chicago/Turabian StyleNoda, Yoshihiro, Mera S. Barr, Reza Zomorrodi, Robin F. H. Cash, Pantelis Lioumis, Robert Chen, Zafiris J. Daskalakis, and Daniel M. Blumberger. 2021. "Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients" Journal of Personalized Medicine 11, no. 1: 54. https://doi.org/10.3390/jpm11010054