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Article

Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients

1
Department of Neuropsychiatry, Graduate School of Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
2
Department of Psychiatry, University of Toronto, Toronto, ON M5T 1R8, Canada
3
Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto, ON M6J 1H4, Canada
4
Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and the Alfred, Melbourne 3004, Australia
5
Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, FI-00076 Espoo, Finland
6
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behaviour—Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, ON M5T 2S8, Canada
7
Department of Psychiatry, UC San Diego Health, San Diego, CA 92093, USA
8
Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, ON M5T 1R8, Canada
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2021, 11(1), 54; https://doi.org/10.3390/jpm11010054
Received: 19 December 2020 / Revised: 14 January 2021 / Accepted: 15 January 2021 / Published: 17 January 2021
Background: The combination of transcranial magnetic stimulation (TMS) with electroencephalography (EEG) allows for non-invasive investigation of cortical response and connectivity in human cortex. This study aimed to examine the amplitudes and latencies of each TMS-evoked potential (TEP) component induced by single-pulse TMS (spTMS) to the left motor (M1) and dorsolateral prefrontal cortex (DLPFC) among healthy young participants (YNG), older participants (OLD), and patients with schizophrenia (SCZ). Methods: We compared the spatiotemporal characteristics of TEPs induced by spTMS among the groups. Results: Compared to YNG, M1-spTMS induced lower amplitudes of N45 and P180 in OLD and a lower amplitude of P180 in SCZ, whereas the DLPFC-spTMS induced a lower N45 in OLD. Further, OLD demonstrated latency delays in P60 after M1-spTMS and in N45-P60 over the right central region after left DLPFC-spTMS, whereas SCZ demonstrated latency delays in N45-P60 over the midline and right central regions after DLPFC-spTMS. Conclusions: These findings suggest that inhibitory and excitatory mechanisms mediating TEPs may be altered in OLD and SCZ. The amplitude and latency changes of TEPs with spTMS may reflect underlying neurophysiological changes in OLD and SCZ, respectively. The spTMS administered to M1 and the DLPFC can probe cortical functions by examining TEPs. Thus, TMS-EEG can be used to study changes in cortical connectivity and signal propagation from healthy to pathological brains. View Full-Text
Keywords: TMS-EEG; TMS-evoked potentials; dorsolateral prefrontal cortex; motor cortex; schizophrenia TMS-EEG; TMS-evoked potentials; dorsolateral prefrontal cortex; motor cortex; schizophrenia
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MDPI and ACS Style

Noda, Y.; Barr, M.S.; Zomorrodi, R.; Cash, R.F.H.; Lioumis, P.; Chen, R.; Daskalakis, Z.J.; Blumberger, D.M. Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients. J. Pers. Med. 2021, 11, 54. https://doi.org/10.3390/jpm11010054

AMA Style

Noda Y, Barr MS, Zomorrodi R, Cash RFH, Lioumis P, Chen R, Daskalakis ZJ, Blumberger DM. Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients. Journal of Personalized Medicine. 2021; 11(1):54. https://doi.org/10.3390/jpm11010054

Chicago/Turabian Style

Noda, Yoshihiro, Mera S. Barr, Reza Zomorrodi, Robin F.H. Cash, Pantelis Lioumis, Robert Chen, Zafiris J. Daskalakis, and Daniel M. Blumberger 2021. "Single-Pulse Transcranial Magnetic Stimulation-Evoked Potential Amplitudes and Latencies in the Motor and Dorsolateral Prefrontal Cortex among Young, Older Healthy Participants, and Schizophrenia Patients" Journal of Personalized Medicine 11, no. 1: 54. https://doi.org/10.3390/jpm11010054

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