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Visualization and Measurements of Blood Cells Flowing in Microfluidic Systems and Blood Rheology: A Personalized Medicine Perspective

by 1,2,*,†, 3, 4, 5 and 3,6
1
Center for MicroElectromechanical Systems (CMEMS-UMinho), Campus de Azurém, University of Minho, 4800-058 Guimarães, Portugal
2
Research Centre in Digitalization and Intelligent Robotics (CeDRI), Campus de Santa Apolónia, Instituto Politécnico de Bragança, 5300-253 Bragança, Portugal
3
MEtRICs, Mechanical Engineering Department, Campus de Azurém, University of Minho, 4800-058 Guimarães, Portugal
4
Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, 1049-001 Lisboa, Portugal
5
ALGORITMI Center (CAlg), University of Minho, 4800-058 Guimarães, Portugal
6
CEFT, Faculdade de Engenharia da Universidade do Porto (FEUP), Rua Dr. Roberto Frias, 4200-465 Porto, Portugal
*
Author to whom correspondence should be addressed.
Current address: INL—International Iberian Nanotechnology Laboratory, Av. Mestre José Veiga, 4715-330 Braga, Portugal.
J. Pers. Med. 2020, 10(4), 249; https://doi.org/10.3390/jpm10040249
Received: 22 September 2020 / Revised: 21 November 2020 / Accepted: 23 November 2020 / Published: 26 November 2020
Hemorheological alterations in the majority of metabolic diseases are always connected with blood rheology disturbances, such as the increase of blood and plasma viscosity, cell aggregation enhancement, and reduction of the red blood cells (RBCs) deformability. Thus, the visualizations and measurements of blood cells deformability flowing in microfluidic devices (point-of-care devices) can provide vital information to diagnose early symptoms of blood diseases and consequently to be used as a fast clinical tool for early detection of biomarkers. For instance, RBCs rigidity has been correlated with myocardial infarction, diabetes mellitus, hypertension, among other blood diseases. In order to better understand the blood cells behavior in microfluidic devices, rheological properties analysis is gaining interest by the biomedical committee, since it is strongly dependent on the interactions and mechanical cells proprieties. In addition, the development of blood analogue fluids capable of reproducing the rheological properties of blood and mimic the RBCs behavior at in vitro conditions is crucial for the design, performance and optimization of the microfluidic devices frequently used for personalized medicine. By combining the unique features of the hemorheology and microfluidic technology for single-cell analysis, valuable advances in personalized medicine for new treatments and diagnosis approach can be achieved. View Full-Text
Keywords: hemorheology; blood diseases; microfluidics; single-cell analysis; red blood cells deformability; blood analogues hemorheology; blood diseases; microfluidics; single-cell analysis; red blood cells deformability; blood analogues
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MDPI and ACS Style

Pinho, D.; Carvalho, V.; Gonçalves, I.M.; Teixeira, S.; Lima, R. Visualization and Measurements of Blood Cells Flowing in Microfluidic Systems and Blood Rheology: A Personalized Medicine Perspective. J. Pers. Med. 2020, 10, 249. https://doi.org/10.3390/jpm10040249

AMA Style

Pinho D, Carvalho V, Gonçalves IM, Teixeira S, Lima R. Visualization and Measurements of Blood Cells Flowing in Microfluidic Systems and Blood Rheology: A Personalized Medicine Perspective. Journal of Personalized Medicine. 2020; 10(4):249. https://doi.org/10.3390/jpm10040249

Chicago/Turabian Style

Pinho, Diana, Violeta Carvalho, Inês M. Gonçalves, Senhorinha Teixeira, and Rui Lima. 2020. "Visualization and Measurements of Blood Cells Flowing in Microfluidic Systems and Blood Rheology: A Personalized Medicine Perspective" Journal of Personalized Medicine 10, no. 4: 249. https://doi.org/10.3390/jpm10040249

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