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Personalized Dentistry: Approaching a New Way for Diagnosis and Treatment of Oral Diseases
Open AccessArticle

Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT

1
Department of Oral Biology, University of Pittsburgh School of Dental Medicine, 412 Salk Pavilion, 335 Sutherland Drive, Pittsburgh, PA 15261, USA
2
Department of Pediatric Dentistry, University of Pittsburgh School of Dental Medicine, Pittsburgh, PA 15213, USA
3
Department of Oral and Maxillofacial Surgery, Positivo University, Curitiba, PR 81280-330, Brazil
4
Department of Pediatric Dentistry, USP, Ribeirão Preto, SP 14040-904, Brazil
5
Department of Morphology, Physiology and Basic Pathology, USP, Ribeirão Preto, SP 14040-904, Brazil
6
Department of Pediatric Dentistry, UNESP, Araraquara, SP 14801-385, Brazil
*
Author to whom correspondence should be addressed.
J. Pers. Med. 2020, 10(2), 44; https://doi.org/10.3390/jpm10020044
Received: 21 April 2020 / Revised: 20 May 2020 / Accepted: 20 May 2020 / Published: 27 May 2020
(This article belongs to the Special Issue Molecular Diagnosis and New Therapeutic Approach of Oral Diseases)
Bruxism is a masticatory muscle activity characterized by grinding of the teeth and clenching of the jaw that causes tooth wear and breakage, temporomandibular joint disorders, muscle pain, and headache. Bruxism occurs in both adults and children. Clinical characteristics and habits were evaluated in an adult sample. Moreover, we used DNA samples from 349 adults and 151 children to determine the presence of association with specific genes. Genomic DNA was obtained from saliva. The markers rs2241145 and rs243832 (metalloproteinase 2 (MMP2)), rs13925 and rs2236416 (metalloproteinase 9 (MMP9)), and rs6269 (cathecol-o-methyltransferase (COMT)) were genotyped. Data were submitted to statistical analysis with a significance level of 0.05. In adults, in univariate logistic regression, presence of caries, attrition, and use of alcohol were increased in bruxism individuals (p < 0.05). In addition, in adults, there was an association between bruxism and MMP9 (rs13925, p = 0.0001) and bruxism and COMT (rs6269, p = 0.003). In children, a borderline association was observed for MMP9 (rs2236416, p = 0.08). When we performed multivariate logistic regression analyses in adults, the same clinical characteristics remained associated with bruxism, and orthodontic treatment was also associated, besides rs13925, in the AG genotype (p = 0.015, ORa: 3.40 (1.27–9.07)). For the first time, we provide statistical evidence that these genes are associate with bruxism. View Full-Text
Keywords: biomarkers; temporomandibular disorders; genetics; matrix metalloproteinases; child dentistry; oral diagnosis biomarkers; temporomandibular disorders; genetics; matrix metalloproteinases; child dentistry; oral diagnosis
MDPI and ACS Style

Vieira, A.R.; Scariot, R.; Gerber, J.T.; Arid, J.; Küchler, E.C.; Sebastiani, A.M.; Palinkas, M.; Díaz-Serrano, K.V.; Torres, C.P.; Regalo, S.C.H.; Nelson-Filho, P.; Bussaneli, D.G.; Deeley, K.; Modesto, A. Bruxism Throughout the Lifespan and Variants in MMP2, MMP9 and COMT. J. Pers. Med. 2020, 10, 44.

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