Next Article in Journal / Special Issue
New Insights into the Molecular Bases of Familial Alzheimer’s Disease
Previous Article in Journal
Neutral, Negative, or Negligible? Changes in Patient Perceptions of Disease Risk Following Receipt of a Negative Genomic Screening Result
Previous Article in Special Issue
The “develOpment of metabolic and functional markers of Dementia IN Older people” (ODINO) Study: Rationale, Design and Methods
Open AccessArticle

The Brain Metabolic Correlates of the Main Indices of Neuropsychological Assessment in Alzheimer’s Disease

1
Department of Biomedicine and Prevention, University Tor Vergata, 00133 Rome, Italy
2
IRCCS Neuromed, 86077 Pozzilli, Italy
3
UOC Nuclear Medicine, Policlinico Tor Vergata, 00133 Rome, Italy
4
UOC Nuclear Medicine, Santa Maria Goretti Hospital, 04100 Latina, Italy
5
UOSD Centro Demenze Policlinico Tor Vergata, 00133 Rome, Italy
6
Department of System Medicine, University Tor Vergata, 00133 Rome, Italy
*
Author to whom correspondence should be addressed.
This paper is a revised version of our paper published as conference paper in the 29th European Association of Nuclear Medicine congress.
J. Pers. Med. 2020, 10(2), 25; https://doi.org/10.3390/jpm10020025
Received: 11 March 2020 / Revised: 14 April 2020 / Accepted: 15 April 2020 / Published: 18 April 2020
(This article belongs to the Special Issue Novel Biomarkers in Alzheimer’s Disease)
Background: The study aimed to investigate the relationships between F-18 fluorodeoxyglucose (18F)FDG uptake and neuropsychological assessment in Alzheimer’s disease (AD). Methods: We evaluated 116 subjects with AD according to the NINCDS-ADRDA criteria. All the subjects underwent a brain PET/CT with (18F)FDG, cerebrospinal fluid (CSF) assay, mini-mental state examination (MMSE) and further neuropsychological tests: Rey auditory verbal learning test, immediate recall (RAVLT immediate); Rey auditory verbal learning test, delayed recall (RAVLT, delayed); Rey complex figure test, copy (RCFT, copy); Rey complex figure test, delayed recall (RCFT, delayed); Raven’s colored progressive matrices (RCPM); phonological word fluency test (PWF) and Stroop test. We performed the statistical analysis by using statistical parametric mapping (SPM12; Wellcome Department of Cognitive Neurology, London, UK). Results: A significant relationship has been reported between (18F)FDG uptake and RAVLT immediate test in Brodmann area (BA)37 and BA22 and with RCFT, copy in BA40, and BA7. We did not find any significant relationships with other tests. Conclusion: In the AD population, brain (18F)FDG uptake is moderately related to the neuropsychological assessment, suggesting a limited impact on statistical data analysis of glucose brain metabolism. View Full-Text
Keywords: Alzheimer’s disease; PET/CT; (18F)FDG; neuropsychological assessment Alzheimer’s disease; PET/CT; (18F)FDG; neuropsychological assessment
Show Figures

Figure 1

MDPI and ACS Style

Chiaravalloti, A.; Ricci, M.; Di Biagio, D.; Filippi, L.; Martorana, A.; Schillaci, O. The Brain Metabolic Correlates of the Main Indices of Neuropsychological Assessment in Alzheimer’s Disease. J. Pers. Med. 2020, 10, 25.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop