Next Article in Journal
Acute Bronchiolitis: Is There a Role for Lung Ultrasound?
Previous Article in Journal
Advanced Heart Failure and End-Stage Heart Failure: Does a Difference Exist
Open AccessReview

Assessment of Metabolic and Nutritional Imbalance in Mechanically Ventilated Multiple Trauma Patients: From Molecular to Clinical Outcomes

1
Faculty of Medicine, “Victor Babes” University of Medicine and Pharmacy, 300041 Timisoara, Romania
2
Clinic of Anaesthesia and Intensive Care, Emergency County Hospital “Pius Brinzeu”,300041 Timisoara 300723, Romania
3
Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, Romania
*
Author to whom correspondence should be addressed.
Diagnostics 2019, 9(4), 171; https://doi.org/10.3390/diagnostics9040171
Received: 9 October 2019 / Revised: 25 October 2019 / Accepted: 31 October 2019 / Published: 1 November 2019
(This article belongs to the Section Pathology and Molecular Diagnostics)
The critically ill polytrauma patient is characterized by a series of metabolic changes induced by inflammation, oxidative stress, sepsis, and primary trauma, as well as associated secondary injuries associated. Metabolic and nutritional dysfunction in the critically ill patient is a complex series of imbalances of biochemical and genetic pathways, as well as the interconnection between them. Therefore, the equation changes in comparison to other critical patients or to healthy individuals, in which cases, mathematical equations can be successfully used to predict the energy requirements. Recent studies have shown that indirect calorimetry is one of the most accurate methods for determining the energy requirements in intubated and mechanically ventilated patients. Current research is oriented towards an individualized therapy depending on the energy consumption (kcal/day) of each patient that also takes into account the clinical dynamics. By using indirect calorimetry, one can measure, in real time, both oxygen consumption and carbon dioxide production. Energy requirements (kcal/day) and the respiratory quotient (RQ) can be determined in real time by integrating these dynamic parameters into electronic algorithms. In this manner, nutritional therapy becomes personalized and caters to the patients’ individual needs, helping patients receive the energy substrates they need at each clinically specific time of treatment.
Keywords: indirect calorimetry; nutrition; metabolism; trauma; intensive care unit indirect calorimetry; nutrition; metabolism; trauma; intensive care unit
MDPI and ACS Style

Rogobete, A.F.; Grintescu, I.M.; Bratu, T.; Bedreag, O.H.; Papurica, M.; Crainiceanu, Z.P.; Popovici, S.E.; Sandesc, D. Assessment of Metabolic and Nutritional Imbalance in Mechanically Ventilated Multiple Trauma Patients: From Molecular to Clinical Outcomes. Diagnostics 2019, 9, 171.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop