CCEO-DCABNet: Chronological Chaotic Evolution Optimization-Enabled Hybrid Deep Learning for Multiclass Disease Classification Using Chest X-Ray Images in Federated Learning
Abstract
1. Introduction
2. Literature Survey
Challenges
- In [15] a multi-stage CNN achieved comprehensive lung illness classification with better predictive accuracy. Still, it did not combine multi-level convolutional and attention functions to improve segmentation performance.
- In [16], CXR-MultiTaskNet was employed as a unified DL for localizing joint disease. Still, this approach struggled due to intensity variations in the smoothing pixel and poor robustness against imaging features.
- SoftLungX in [17] classified chest X-ray images into radiological findings and disease categories with quick processing. Nonetheless, it failed to localize pictorial depictions for classifying and measuring disease severity
- LungMaxViT in [18] incorporated a multi-axis transformer with a CNN backbone for improving robustness of classification. Although this model captured both local and global features, it failed to analyze the osteoporosis condition.
- Classification of lung disease automatically detects and categorizes respiratory illnesses, like tuberculosis, pneumonia, lung cancer, and other illnesses. Detection and classification of disease improve treatment planning as per disease types. Due to class imbalance, limited annotated data, interpretability issues, and inconsistency in imaging quality, the detection of multiclass disease becomes complex.
3. System Model for Federated Assessment Using Chest X-Ray Images

3.1. Chronological Chaotic Evolution Optimization-Enabled Deep Channel-Attention Broad Convolutional Neural Network
3.2. Training of Local Model by Local Data
3.2.1. Training of Every Node
3.2.2. Training Model
3.2.3. Acquisition of Data for Intrusion Detection
3.2.4. Input Image Pre-Preparation:
- 1.
- Denoising using Gaussian Filter:The image is denoised using Gaussian filtering, where a Gaussian function is applied to suppress noise and smooth the image. This filtering operation produces a visually uniform blur, similar to the bokeh effect caused by object shadows under illumination. Consequently, the smoothing process enhances the perceptual quality of the image at multiple scales. The resulting denoised image is represented as .
- 2.
- Sharpening using Multiscale Unsharp Masking:Multiscale unsharp masking is employed to enhance image sharpness by subtracting the blurred components from the original image. In this approach, three Gaussian kernels of different sizes are utilized to generate multiple blurred versions of the image. These multiscale blurred representations help preserve fine details while improving edge clarity and overall image contrast.
3.2.5. Segmentation of Lung Lobe by MMPU-Net
- 1.
- Structure of MMPU-NetSharpened image is subjected to MMPU-Net for segmenting lung lobe, and it is displayed in Figure 3. Coarse and fine segmentation are the two stages, in which fine segmentation is done by creating a predictive mask and then localizing the pancreas. After cropping the region of interest (ROI), bounding box of the pancreas is extracted to detect extreme coordinates. Finally, the cropped area is refined at a fine stage for obtaining the segmented output . Encoder, inverted residual addition, decoder, and bottleneck are major parts of MMPU-Net. Encoder covers four stages, where blocks 0 to 13 are selected among the 17 blocks. Channel count of encoder layer is 32, and extracts transitional feature maps from four expanded ReLU blocks 13, 6, 3, and 1. Here, depthwise convolution (Conv) with stride 2 is employed for downsampling, and feature maps of such blocks are concatenated to feature map of upsampling. MMPU-Net includes inverted residual addition for preserving data and improving training stability. After yielding an intermediate outcome from Conv, the dimension adjustment performs direct addition between the input and intermediate output. Decoder of MMPU-Net is based on the U-Net structure, which includes skip contacts and progressive upsampling for restoring spatial details. The Conv filters of the decoder include 3 × 3 dimension kernel to offer even feature extraction. Moreover, the decoder performs gradual drop of feature channels by increasing spatial resolution. Point-block and MM-block are employed as an attention unit of the bottleneck unit. MM-block is used as a Conv-based attention with pooling paths, where the primary pathway depends on average pooling and secondary utilizes maxpooling. Here, input feature of the MM-block is represented by and f undergoes average and max pooling. The outcome of these functions is merged to improve learned description features. Further, mean, and average pooling on the channel axis is computed byHere, z indicates channel and specifies spatial indices of the features. Afterward, is convolved to a single 3 × 3 kernel for adjusting its sizes and creating . Hence, output dimension of is equal to dimensionality of K. The Conv function is given byHere, implies Conv kernel at and . Using mean-max attention map , sigmoid activation becomes

3.2.6. Radiomic Feature Extraction from Segmented Image
- 1.
- CompactnessCompactness [29] is employed for measuring degree of curvature, and it is represented as the proportion of inner region of the image to the perimeter.Compactness is specified by , implies area of , and denotes the perimeter .
- 2.
- SolidityThe fraction of inner region of segmented image to convex area is termed as solidity [29], and it is given bySolidity is denoted by , and implies convex area of .
- 3.
- EccentricityEccentricity [29] indicates a relation between the extensive to the shortest straight line in the image, as represented byHere, implies Eccentricity.
- 4.
- RoundnessRoundness [29] is equivalent to compactness, but it utilizes perimeter of a convex instead of the region’s perimeter.where symbolizes perimeter of a convex, and specifies Roundness.
3.2.7. Classification of Multiclass Disease by CCEO-DCABNet
Structure of DCABNet
- In DCACorrCapsNet: The vector passes through a localized dense (fully connected) layer to project it into a higher-dimensional embedding space matching the capsule dimensions before undergoing spatial routing. The primary output represents a high-level capsule tensor.
- In ADBNet: The vector acts as a calibration weight via element-wise multiplication with the attention-guided convolutional maps ( and ), acting as a structural regularizer.
- 1.
- DCACorrCapsNetDCACorrCapsNet [31] covers multi-feature extraction, hierarchical capsule, and classification modules, where the feature vector is considered as input. Multi-feature extraction performs augmentation, channel attention, and the Fisher vector module. Augmentation minimizes overfitting problems and uses geometric transformations to enhance the image. In Fisher vector, regularization normalizes numerical distribution. Conv kernels in the channel attention stage generate feature maps by aggregation of spatial dimensionality. The initial capsule constructs a set of parallel Conv layers, where each capsule in the correlative capsule layer independently extracts salient attributes and local structural details. In the classification module, outcome of the multi-level capsule with the feature extractor is applied to DeepGBM to obtain .Here, weight is portrayed by .
- 2.
- ADBNetADBNet [30] improves feature depiction by including a deep network with attention functions. Input is fed to ADBNet to attain , where the residual module attains superior learning from prior layers. It also contains different processing layers for refining input. In attention guided phase, CBAM focuses on informative details to suppress less appropriate features. Integration of modified CBAM with CNN is employed for learning rich descriptions of salient features. Deep, broad stage offers the learning of broader spectrum of data using a deep network style. Here, input features are fed to sequence of Conv and activation layers to create intermediate feature maps. Merging of fully connected and combination of global average layer creates a feature e.Here, implies a fully connected layer, as well as output, input, and intermediate features are denoted by e, i and h. The outcome of ADBNet is given by.Here, specifies the concatenation function.
- 3.
- Taylor conceptTaylor concept [32] specifies a mathematical illustration of an infinite series, where and are applied to the Taylor series to achieve the detected output .Mathematically, the hybrid feature map is derived by approximating the underlying non-linear interaction function via a second-order Taylor series expansion centered around a localized deep feature consensus :where and represent the multi-feature capsule routing map from the DCACorrCapsNet and the attention-guided map from the ADBNet, respectively. By projecting these variables into an interrelated Taylor expansion space, the network preserves structural gradients and bridges the optimization void between mathematical radiomics and neural attention. This unified optimization loop forms the core structural innovation of the CCEO-DCABNet framework, preventing cross-module information loss during distributed federated roundsFrom Equation (22), outcome of DCABNet is obtained.
Training of DCABNet Using CCEO
| Algorithm 1: Pseudocode for CCEO. |
|
3.3. Aggregation on Global Server
4. Results and Discussion
4.1. Experimental Setup
4.2. Description of Dataset
4.2.1. NIH Chest X-Ray Dataset
4.2.2. Pulmonary Edema Dataset
4.3. Metrics for Evaluation
4.3.1. Accuracy
4.3.2. TPR
4.3.3. TNR
4.4. Experimental Outcome
4.5. Explainability Assessment
4.6. ROC Curve
4.7. Confusion Matrix
4.8. Assessment of CCEO-DCABNet
4.8.1. Federated Assessment
- 1.
- Evaluation using NIH Chest X-ray DatasetFigure 12 shows Federated assessment of CCEO-DCABNet using NIH Chest X-ray dataset. Analysis regarding accuracy is deliberated in Figure 12a. Here, CCEO-DCABNet attains an accuracy of , , , and while local nodes are varied from 2 to 10. Figure 12b displays the evaluation regarding TPR. The TPR attained by CCEO-DCABNet at local node 2 is , 4 is , 6 is , 8 is , and 10 is Figure 12c portrays an estimation concerning TNR, and TNRs of , , , , and are attained by CCEO-DCABNet at local nodes 2–10.
- 2.
- Evaluation using Pulmonary Edema datasetFederated evaluation of CCEO-DCABNet using the Pulmonary Edema dataset is portrayed in Figure 13. Figure 13a deliberates an evaluation concerning accuracy. At local nodes from 2 to 10, accuracy of , , , , and are attained by CCEO-DCABNet. Evaluation regarding TPR is deliberated in Figure 13b, where TPR attained by CCEO-DCABNet at local nodes 2–10 are , , , and . Figure 13c portrays an analysis regarding TNR. Here, CCEO-DCABNet attains TPRs at local node 2 is , 4 is , 6 is , 8 is , and 10 is .
4.8.2. K-Fold Assessment
- 1.
- Assessment using NIH Chest X-ray DatasetFigure 14 deliberates K-Fold valuation of CCEO-DCABNet by NIH Chest X-ray dataset. Assessment regarding accuracy is shown in Figure 14a. Existing models and CCEO-DCABNet attain an accuracy of , , , , and . Thus, CCEO-DCABNet achieves , , , , and of superior performance than existing models. Figure 14b displays an estimation regarding TPR, where TPR achieved by CCEO-DCABNet is , and existing techniques attain the values , , , and . Hence, CCEO-DCABNet attains , , , , and of improved performance. Figure 14c portrays an evaluation concerning TNR. Here, existing models, and CCEO-DCABNet attains , , , , , and of TNR. Hence, performance improvement of , , , , and is achieved by CCEO-DCABNet.
- 2.
- Assessment using Pulmonary Edema datasetK-Fold evaluation of CCEO-DCABNet using the Pulmonary Edema dataset is illustrated in Figure 15. Figure 15a deliberates an evaluation of accuracy. The CCEO-DCABNet and other methods attain , , , , , and of accuracy. Hence, an improved performance of , , , and is attained by CCEO-DCABNet than others. Analysis regarding TPR is depicted in Figure 15b, where TPR of , , , , , and are achieved by existing models, and CCEO-DCABNet. As a result, CCEO-DCABNet attains better performance of , , , , and . Figure 15c displays an estimation concerning TNR, where values achieved by CCEO-DCABNet is , and existing models are , , , , and . Thus, CCEO-DCABNet achieves performance improvement of , , , and than other methods.
4.9. Discussion
4.9.1. Comparative Discussion
4.9.2. Wilcoxon Test
4.9.3. Convergence Analysis
4.10. Ablation Studies
- w/o Image Pre-preparation: Bypassing the initial Gaussian filter-enabled denoising and multiscale unsharp masking-enabled sharpening steps.
- w/o MMPU-Net Segmentation: Removing the automated lung lobe segmentation pipeline, thereby forcing the deep learning streams to process the unsegmented, raw global chest X-ray.
- w/o Radiomic Features: Retaining the segmented regions but completely omitting the extraction of statistical radiomic features (Solidity, Compactness, Roundness, and Eccentricity) from the pipeline.
- w/o Capsule Network: Disabling the deep channel-attention correlative capsule module (DCACorrCapsNet).
- w/o Neural Attention: Isolating the core fusion network from the attention-guided network stream (ADBNet).
- w/o Taylor Fusion (Empirical Concatenation): Replacing the second-order Taylor series expansion mapping with standard empirical feature vector concatenation.The quantitative performance metrics across both the NIH Chest X-ray and Pulmonary Edema datasets are compiled in Table 5.
4.11. Computational Complexity
- Local Latency: Image preprocessing (Gaussian filtering and multiscale unsharp masking) and MMPU-Net segmentation require an average of and per chest X-ray, respectively. Computing the explicit radiomic vector introduces a negligible latency of <.
- Training and Convergence: Using a local batch size of 32, a single localized training epoch takes approximately 3.2 min. Guided by the CCEO algorithm, local sub-networks reach optimal stability within , while the global federated system achieves complete convergence within .
- Inference Speed: Post-deployment, the end-to-end inference latency for an unseen patient image is . This near-real-time performance validates the network’s readiness for high-throughput clinical triage.
4.12. Clinical Evaluation and Real-World Deployment Scenarios
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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| Simulated Node ID | Target Dataset Source | Normal Class (Images) | Pneumonia Class (Images) | Pleural Effusion Class (Images) | Total Allocated Images |
|---|---|---|---|---|---|
| Client Node 1 | NIH Chest X-Ray | 15,000 | 2500 | 3000 | 20,500 |
| Client Node 2 | NIH Chest X-Ray | 12,000 | 4000 | 2200 | 18,200 |
| Client Node 3 | NIH Chest X-Ray | 14,500 | 1500 | 4100 | 20,100 |
| Client Node 4 | Pulmonary Edema | 300 | 450 (Alveolar/Interstitial) | 250 (Vascular Congestion) | 1000 |
| Global Test Set | Combined (20% Holdout) | 8360 | 1690 | 1910 | 11,960 |
| Parameters | Values |
|---|---|
| Highest iteration | 100 |
| Scaling factor | 0.5 |
| Random value | [0, 1] |
| Dimensions | 50 |
| Population dimension | 50 |
| Lower bound | |
| Upper bound | 100 |
| Learning rate | 0.001 |
| Batch size | 64 |
| Epochs | 100 |
| Kernel size | |
| Padding | Same |
| Stride | 1 |
| Activation (convolution layer) | ReLU |
| Filter size | 64–128 |
| Loss function | Categorical cross-entropy |
| Dimension of capsules | 8 |
| Optimizer | CCEO |
| Number of capsules | 32 |
| Activation (dense layer) | Softmax |
| Datasets | Metrics/Methods | Multi-Stage CNN | CXR-MultiTask Net | SoftLungX | LungMax ViT | DCAB Net | CCEO_DCABNet |
|---|---|---|---|---|---|---|---|
| NIH Chest X-ray Dataset | Accuracy (%) | 88.34 | 91.25 | 92.32 | 94.02 | 96.12 | 96.74 |
| TPR (%) | 87.63 | 89.41 | 91.32 | 93.21 | 95.52 | 96.21 | |
| TNR (%) | 88.63 | 91.32 | 93.54 | 94.32 | 96.21 | 97.12 | |
| Pulmonary Edema Dataset | Accuracy (%) | 88.38 | 90.32 | 92.14 | 94.12 | 96.32 | 96.98 |
| TPR (%) | 87.63 | 89.36 | 91.34 | 93.65 | 95.82 | 96.41 | |
| TNR (%) | 89.35 | 91.36 | 92.36 | 94.22 | 96.41 | 97.45 |
| Comparative Methods | Multi-Stage CNN | CXR-MultiTaskNet | SoftLungX | LungMaxViT | DCABNet | ||
|---|---|---|---|---|---|---|---|
| NIH Chest X-ray Dataset | Wilcoxon-statistic | Accuracy | 2.96 | 2.84 | 2.48 | 2.17 | 2.11 |
| TPR | 2.98 | 2.89 | 2.56 | 2.31 | 2.22 | ||
| TNR | 2.92 | 2.68 | 2.37 | 2.12 | 2.09 | ||
| p-value | Accuracy | 0.035 | 0.033 | 0.025 | 0.015 | 0.012 | |
| TPR | 0.042 | 0.038 | 0.031 | 0.024 | 0.018 | ||
| TNR | 0.029 | 0.029 | 0.022 | 0.012 | 0.009 | ||
| Pulmonary Edema Dataset | Wilcoxon-Statistic | Accuracy | 2.84 | 2.58 | 2.29 | 2.11 | 2.14 |
| TPR | 2.91 | 2.69 | 2.51 | 2.25 | 2.28 | ||
| TNR | 2.75 | 2.49 | 2.21 | 2.04 | 2.08 | ||
| p-value | Accuracy | 0.031 | 0.026 | 0.018 | 0.012 | 0.007 | |
| TPR | 0.035 | 0.028 | 0.022 | 0.015 | 0.011 | ||
| TNR | 0.027 | 0.021 | 0.016 | 0.009 | 0.005 | ||
| Model Configuration | Dataset | Accuracy (%) | TPR (%) | TNR (%) |
|---|---|---|---|---|
| Complete CCEO-DCABNet | NIH Chest X-ray | 96.74% | 96.21% | 97.12% |
| Pulmonary Edema | 96.98% | 96.41% | 97.45% | |
| 1. w/o Image Pre-preparation | NIH Chest X-ray | 91.15% | 90.86% | 91.50% |
| Pulmonary Edema | 92.05% | 91.12% | 92.40% | |
| 2. w/o MMPU-Net Segmentation | NIH Chest X-ray | 92.30% | 91.54% | 93.12% |
| Pulmonary Edema | 91.80% | 91.02% | 92.65% | |
| 3. w/o Radiomic Features | NIH Chest X-ray | 93.12% | 92.40% | 93.75% |
| Pulmonary Edema | 92.95% | 92.10% | 93.50% | |
| 4. w/o DCACorrCapsNet | NIH Chest X-ray | 93.45% | 92.90% | 94.02% |
| Pulmonary Edema | 93.10% | 92.45% | 93.88% | |
| 5. w/o ADBNet | NIH Chest X-ray | 94.12% | 93.55% | 94.80% |
| Pulmonary Edema | 93.95% | 93.15% | 94.60% | |
| 6. w/o Taylor Fusion (Concatenation) | NIH Chest X-ray | 90.28% | 89.65% | 91.10% |
| Pulmonary Edema | 90.50% | 89.92% | 91.35% |
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Patil, L.; Garg, B.; Donelli, M.; Jain, A. CCEO-DCABNet: Chronological Chaotic Evolution Optimization-Enabled Hybrid Deep Learning for Multiclass Disease Classification Using Chest X-Ray Images in Federated Learning. Diagnostics 2026, 16, 2096. https://doi.org/10.3390/diagnostics16132096
Patil L, Garg B, Donelli M, Jain A. CCEO-DCABNet: Chronological Chaotic Evolution Optimization-Enabled Hybrid Deep Learning for Multiclass Disease Classification Using Chest X-Ray Images in Federated Learning. Diagnostics. 2026; 16(13):2096. https://doi.org/10.3390/diagnostics16132096
Chicago/Turabian StylePatil, Leena, Bindu Garg, Massimo Donelli, and Achin Jain. 2026. "CCEO-DCABNet: Chronological Chaotic Evolution Optimization-Enabled Hybrid Deep Learning for Multiclass Disease Classification Using Chest X-Ray Images in Federated Learning" Diagnostics 16, no. 13: 2096. https://doi.org/10.3390/diagnostics16132096
APA StylePatil, L., Garg, B., Donelli, M., & Jain, A. (2026). CCEO-DCABNet: Chronological Chaotic Evolution Optimization-Enabled Hybrid Deep Learning for Multiclass Disease Classification Using Chest X-Ray Images in Federated Learning. Diagnostics, 16(13), 2096. https://doi.org/10.3390/diagnostics16132096

