Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design and Participants
2.2. CD4+ Analysis
2.3. Measurement of Viral Load
2.4. Determination of Cytokine Levels
2.5. Statistical Analysis
3. Results
3.1. Baseline Characteristics
3.2. Cytokine Measurement
3.3. Diagnostic Performance of IL-6 and IL-10
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Characteristic | HIV-INRs (n = 15) | HIV-IRs (n = 25) | p-Value |
---|---|---|---|
Age (years) | |||
Median (min–max) | 35 (24–50) | 36 (24–51) | 0.695 |
Gender | |||
Male | 15 (100.0%) | 17 (68.0%) | 0.014 |
Female | 0 (0.0%) | 8 (32.0%) | |
Duration of ART (years) | |||
Median (min–max) | 2 (1–10) | 5 (1–16) | 0.036 |
CD4+ T cells (cell/µL) | |||
Mean ± SD | 232.8 ± 62.5 | 570.2 ± 191.9 | <0.001 |
Nadir CD4+ T cells (cell/µL) | |||
Median (min–max) | 85 (19–224) | 232 (54–663) | <0.001 |
Body Mass Index (kg/m2) | |||
Mean ± SD | 21.4 ± 2.4 | 21.4 ± 1.8 | 0.968 |
Coinfection | 12 (80%) | 13 (52%) | |
Active Tuberculosis | 2 (18.2%) | 1 (5.9%) | 0.087 |
Hepatitis B | 2 (18.2%) | 0 (0.0%) | |
Hepatitis C | 0 (0.0%) | 4 (23.5%) | |
Syphilis | 4 (36.4%) | 0 (0.0%) | |
No coinfection | 3 (27.2%) | 12 (70.6%) |
Cytokine (pg/mL) | HIV-INRs (n = 15) | HIV-IRs (n = 25) | p-Value |
---|---|---|---|
IL-17A | 2.87 (0.00–52.52) | 1.74 (0.00–10.64) | 0.190 |
IFN-γ | 0.06 (0.00–3.23) | 0.01 (0.00–2.14) | 0.860 |
IL-4 | 0.39 (0.00–7.07) | 0.39 (0.00–1.34) | 0.557 |
IL-2 | 0.23 (0.00–2.07) | 0.02 (0.00–0.54) | 0.097 |
IL-6 | 1.84 (1.13–6.01) | 0.94 (0.58–1.40) | 0.016 |
IL-10 | 1.65 (0.36–11.30) | 0.92 (0.40–1.51) | 0.031 |
Cytokine (pg/mL) | AUC | Cut-Off (pg/mL) | Sensitivity | Specificity |
---|---|---|---|---|
IL-6 | 0.731 | 1.215 | 0.667 | 0.360 |
IL-10 | 0.707 | 1.085 | 0.600 | 0.360 |
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Indrati, A.R.; Kosasih, F.N.; Fadhilah, F.; Pratiwi, A.; Muthiah, U.; Logito, V.; Sumarpo, A.; Haryanto, J.; Munaya, S.; Rosmiati, N.M.D.; et al. Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population. Diagnostics 2025, 15, 959. https://doi.org/10.3390/diagnostics15080959
Indrati AR, Kosasih FN, Fadhilah F, Pratiwi A, Muthiah U, Logito V, Sumarpo A, Haryanto J, Munaya S, Rosmiati NMD, et al. Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population. Diagnostics. 2025; 15(8):959. https://doi.org/10.3390/diagnostics15080959
Chicago/Turabian StyleIndrati, Agnes Rengga, Felicia Nathania Kosasih, Fitri Fadhilah, Amelia Pratiwi, Ummi Muthiah, Verina Logito, Anton Sumarpo, Jane Haryanto, Shofa Munaya, Ni Made Dwi Rosmiati, and et al. 2025. "Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population" Diagnostics 15, no. 8: 959. https://doi.org/10.3390/diagnostics15080959
APA StyleIndrati, A. R., Kosasih, F. N., Fadhilah, F., Pratiwi, A., Muthiah, U., Logito, V., Sumarpo, A., Haryanto, J., Munaya, S., Rosmiati, N. M. D., Turbawaty, D. K., & Wisaksana, R. (2025). Elevated Levels of Pro-Inflammatory Interleukin-6 in HIV Immunological Non-Responders Among the Indonesian Population. Diagnostics, 15(8), 959. https://doi.org/10.3390/diagnostics15080959