An Incidental Finding of Appendiceal Gastrointestinal Stromal Tumor with Abundant Skeinoid Fibers: A Rare Case Report with Insights from a Comprehensive Literature Review
Abstract
:1. Introduction
2. Case Presentation
3. Discussion and Literature Review
Case No. | Reference | Age | Gender | Symptoms | Location | Size (cm) | Histology | Risk Classification | Coexisting Malignancy | Genotype | Outcome |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | Markku Miettinen et al., 2001 [6] | 64 | M | Incidental (autopsy) | Tip | 1.4 | Spindle cell: SF+ | Low risk | Metastatic pulmonary adenocarcinoma | N/A | Died (unrelated) |
2 | Markku Miettinen et al., 2001 [6] | 56 | M | Appendicitis-like | Proximal | 1.2 | Spindle cell; SF+ | Low risk | None | N/A | Alive at 8 Y |
3 | Markku Miettinen et al., 2001 [6] | 59 | M | Incidental | N/A | 0.9 | Spindle cell; SF+ | Low risk | Gastric epithelioid GIST | N/A | Died at 15 Y (liver metastasis from gastric GIST) |
4 | Markku Miettinen et al., 2001 [6] | 72 | M | Appendicitis | Proximal | 1.3 | Spindle cell | N/A | None | N/A | Died at 4 Y (COPD) |
5 | W. M. Yap et al., 2005 [8] | 66 | F | Appendicitis-like | Mid portion | 0.25 | Spindle cell | Low risk | NF2 | N/A | N/A |
6 | Kyu-Jong Kim et al., 2007 [20] | 56 | M | GI bleeding | Mid portion | <1 | Spindle cell | Low risk | None | N/A | No recurrence at 3 M |
7 | A. Agaimy et al., 2008 [4] | 72 | M | Incidental | Tip | 2.5 | Spindle cell; focal epithelioid | Low risk | Urinary bladder carcinoma | KIT inframe deletion I571_R588 (Exon 11) | No recurrence at 4 M |
8 | A. Agaimy et al., 2008 [4] | 78 | F | Appendicitis-like | Proximal | 0.5 | Spindle cell; SF+ | Very low risk | Endometrial adenocarcinoma | KIT K558R (Exon11) | N/A |
9 | A. Agaimy et al., 2008 [5] | 86 | F | N/A | N/A | <1 | Spindle cell | Very low risk | None | Wild type | N/A |
10 | Kurosh Rahimi et al., 2009 [7] | 65 | F | Incidental | N/A | 1.1 | Epithelioid and spindle cell; nerve differentiation | Very low risk | Mantle cell lymphoma with appendiceal involvement | Wild type | No recurrence at 24 M |
11 | Ram Elazary et al. [19] | 57 | M | Abdominal pain and peri-appendiceal abscess | Tip | 20 | Spindle cells | Malignant (invading adjacent bowel) | None | N/A | N/A |
12 | Wenhua Li et al., 2012 [3] | 6 | M | Abdominal pain and hard mass | Mesoappendix | 6.7 | Spindle and epithelioid cell | Malignant | None | N/A | No recurrence at 9 M |
13 | M. Bouassida et al., 2013 [21] | 75 | M | Appendicitis, perforation, and acute peritonitis | Mid portion | 2.0 | Spindle cell | Low risk | None | N/A | No recurrence at 48 M |
14 | Nikolaos Vassos et al., 2013 [13] | 48 | M | Appendicitis-like | N/A | 3.0 | Spindle cell | High risk (tumor rupture) | None | KIT 558-559del and 559-560ins (Exon11) | No recurrence at 27 M |
15 | J. M. Chun and K. H. Lim, 2016 [22] | 68 | M | Appendicitis | Proximal | 3.0 | Spindle cell | Low risk | None | N/A | No recurrence at 35 M |
16 | M. Kaneko et al., 2017 [18] | 67 | M | Large abdominal mass | Tip | 22.0 | Spindle cell | Malignant (peritoneal metastasis) | None | N/A | No recurrence at 6 M |
17 | Bao Zhang et al., 2018 [23] | 59 | F | Incidental | N/A | 10 | N/A | High risk | Cervical cancer | N/A | N/A |
18 | N. Mourra et al., 2020 [10] | 61 | M | Appendicitis-like symptoms | Proximal | 1.0 | Spindle cell; SF+ | Very low risk | None | N/A | N/A |
19 | Ahmad Elnassasra et al., 2022 [24] | 75 | M | Appendicitis | Tip | <1 | Spindle cell | Low risk | None | N/A | N/A |
20 | Jacob D. Williams et al., 2024 [25] | 74 | M | Abdominal pain; appendiceal mass | Mid portion | 1.5 | Spindle cell | Low risk | None | N/A | No recurrence at 2 M |
Our case | 74 | M | Incidental | Proximal | 1.2 | Spindle cell; SF+ | Very low risk | Colonic adenocarcinoma | N/A | No recurrence at 4 M |
4. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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Liu, Y.; Chen, Y.; Feroze, A.; Fu, Z. An Incidental Finding of Appendiceal Gastrointestinal Stromal Tumor with Abundant Skeinoid Fibers: A Rare Case Report with Insights from a Comprehensive Literature Review. Diagnostics 2025, 15, 924. https://doi.org/10.3390/diagnostics15070924
Liu Y, Chen Y, Feroze A, Fu Z. An Incidental Finding of Appendiceal Gastrointestinal Stromal Tumor with Abundant Skeinoid Fibers: A Rare Case Report with Insights from a Comprehensive Literature Review. Diagnostics. 2025; 15(7):924. https://doi.org/10.3390/diagnostics15070924
Chicago/Turabian StyleLiu, Yu, Yaomin Chen, Asra Feroze, and Zhiyan Fu. 2025. "An Incidental Finding of Appendiceal Gastrointestinal Stromal Tumor with Abundant Skeinoid Fibers: A Rare Case Report with Insights from a Comprehensive Literature Review" Diagnostics 15, no. 7: 924. https://doi.org/10.3390/diagnostics15070924
APA StyleLiu, Y., Chen, Y., Feroze, A., & Fu, Z. (2025). An Incidental Finding of Appendiceal Gastrointestinal Stromal Tumor with Abundant Skeinoid Fibers: A Rare Case Report with Insights from a Comprehensive Literature Review. Diagnostics, 15(7), 924. https://doi.org/10.3390/diagnostics15070924