Next Article in Journal
Adult Acquired Flatfoot Deformity: A Narrative Review about Imaging Findings
Next Article in Special Issue
Styloid Jugular Nutcracker: The Possible Role of the Styloid Process Spatial Orientation—A Preliminary Morphometric Computed Study
Previous Article in Journal
The Nuclear Dense Fine Speckled (DFS) Immunofluorescence Pattern: Not All Roads Lead to DFS70/LEDGFp75
Previous Article in Special Issue
Subtypes of the Completely Reversed Flow Waveform in Vertebral Artery Can Help to Differentiate Subclavian Artery Occlusion from Severe Stenosis
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 13
Issue 2
10.3390/diagnostics13020224
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19

by
Giulia Renda
1,2,
Marco G. Mennuni
3,*,
Giovanni Pizzoferrato
1,2,
Daniele Esposto
1,2,
Angela Alberani
1,2,
Simona De Vecchi
3,
Anna Degiovanni
3,
Ailia Giubertoni
3,
Enrico Guido Spinoni
4,
Leonardo Grisafi
4,
Emanuele Sagazio
4,
Claudio Ucciferri
2,5,
Katia Falasca
2,5,
Jacopo Vecchiet
2,5,
Sabina Gallina
1 and
Giuseppe Patti
3,4
1
Institute of Cardiology, Department of Neuroscience, Imaging and Clinical Sciences, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
2
SS. Annunziata Hospital of Chieti, 66100 Chieti, Italy
3
Maggiore della Carità Hospital, 28100 Novara, Italy
4
Translational Medicine Department, University of Eastern Piedmont, 28100 Novara, Italy
5
Clinic of Infectious Diseases, Department of Medicine and Science of Aging, G. d’Annunzio University of Chieti-Pescara, 66100 Chieti, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2023, 13(2), 224; https://doi.org/10.3390/diagnostics13020224
Submission received: 22 October 2022 / Revised: 7 December 2022 / Accepted: 29 December 2022 / Published: 7 January 2023
(This article belongs to the Collection Vascular Diseases Diagnostics)
Browse Figures
Versions Notes

Abstract

Background: Echocardiographic Pulmonary to Left Atrial Ratio (ePLAR) represents an accurate and sensitive non-invasive tool to estimate the trans-pulmonary gradient. The prognostic value of ePLAR in hospitalized patients with COVID-19 remains unknown. We aimed to investigate the predictive value of ePLAR on in-hospital mortality in patients with COVID-19. Methods: One hundred consecutive patients admitted to two Italian institutions for COVID-19 undergoing early (<24 h) echocardiographic examination were included; ePLAR was determined from the maximum tricuspid regurgitation continuous wave Doppler velocity (m/s) divided by the transmitral E-wave: septal mitral annular Doppler Tissue Imaging e′-wave ratio (TRVmax/E:e′). The primary outcome measure was in-hospital death. Results: patients who died during hospitalization had at baseline a higher prevalence of tricuspid regurgitation, higher ePLAR, right-side pressures, lower Tricuspid Annular Plane Systolic Excursion (TAPSE)/ systolic Pulmonary Artery Pressure (sPAP) ratio and reduced inferior vena cava collapse than survivors. Patients with ePLAR > 0.28 m/s at baseline showed non-significant but markedly increased in-hospital mortality compared to those having ePLAR ≤ 0.28 m/s (27% vs. 10.8%, p = 0.055). Multivariate Cox regression showed that an ePLAR > 0.28 m/s was independently associated with an increased risk of death (HR 5.07, 95% CI 1.04–24.50, p = 0.043), particularly when associated with increased sPAP (p for interaction = 0.043). Conclusions: A high ePLAR value at baseline predicts in-hospital death in patients with COVID-19, especially in those with elevated pulmonary arterial pressure. These results support an early ePLAR assessment in patients admitted for COVID-19 to identify those at higher risk and potentially guide strategies of diagnosis and care.
Keywords: ePLAR; pulmonary embolism; trans-pulmonary pressure gradient; COVID-19; in-hospital mortality ePLAR; pulmonary embolism; trans-pulmonary pressure gradient; COVID-19; in-hospital mortality

Share and Cite

MDPI and ACS Style

Renda, G.; Mennuni, M.G.; Pizzoferrato, G.; Esposto, D.; Alberani, A.; De Vecchi, S.; Degiovanni, A.; Giubertoni, A.; Spinoni, E.G.; Grisafi, L.; et al. Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19. Diagnostics 2023, 13, 224. https://doi.org/10.3390/diagnostics13020224

AMA Style

Renda G, Mennuni MG, Pizzoferrato G, Esposto D, Alberani A, De Vecchi S, Degiovanni A, Giubertoni A, Spinoni EG, Grisafi L, et al. Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19. Diagnostics. 2023; 13(2):224. https://doi.org/10.3390/diagnostics13020224

Chicago/Turabian Style

Renda, Giulia, Marco G. Mennuni, Giovanni Pizzoferrato, Daniele Esposto, Angela Alberani, Simona De Vecchi, Anna Degiovanni, Ailia Giubertoni, Enrico Guido Spinoni, Leonardo Grisafi, and et al. 2023. "Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19" Diagnostics 13, no. 2: 224. https://doi.org/10.3390/diagnostics13020224

APA Style

Renda, G., Mennuni, M. G., Pizzoferrato, G., Esposto, D., Alberani, A., De Vecchi, S., Degiovanni, A., Giubertoni, A., Spinoni, E. G., Grisafi, L., Sagazio, E., Ucciferri, C., Falasca, K., Vecchiet, J., Gallina, S., & Patti, G. (2023). Predictive Value of Echocardiographic Pulmonary to Left Atrial Ratio for In-Hospital Death in Patients with COVID-19. Diagnostics, 13(2), 224. https://doi.org/10.3390/diagnostics13020224

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop