Osteonecrosis of the Femoral Head: A Multidisciplinary Approach in Diagnostic Accuracy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design
2.2. Patients
2.3. Diagnosis
2.4. Histological Analysis
2.5. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Conflicts of Interest
References
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Specimen | Surgeon Pre-Surgery | Surgeon Post-Surgery | Radiologist | Pathologist | Disagreement |
---|---|---|---|---|---|
1 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
2 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
3 (CASE) | AVNH | AVNH | OA | AVNH | Radiologist vs. others |
4 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
5 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
6 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
7 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
8 (CASE) | OA | OA | OA | AVNH | Pathologist vs. others |
9 (CASE) | OA | OA | AVNH | AVNH | Surgeon vs. others |
10 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
11 (CASE) | AVNH | AVNH | AVNH | AVNH | NO |
12 (CASE) | OA | OA | OA | AVNH | Pathologist vs. others |
13 (CONTROL) | OA | AVNH | OA | OA | Surgeon vs. others |
14 (CONTROL) | OA | OA | OA | OA | NO |
15 (CONTROL) | OA | OA | OA | OA | NO |
16 (CONTROL) | OA | OA | OA | OA | NO |
17 (CONTROL) | OA | OA | OA | OA | NO |
18 (CONTROL) | OA | OA | OA | AVNH | Pathologist vs. others |
19 (CONTROL) | OA | OA | OA | OA | NO |
20 (CONTROL) | OA | OA | OA | OA | NO |
21 (CONTROL) | OA | OA | OA | OA | NO |
22 (CONTROL) | OA | OA | OA | AVNH | Pathologist vs. others |
23 (CONTROL) | OA | OA | OA | OA | NO |
24 (CONTROL) | OA | OA | OA | OA | NO |
ONFH (Mean ± SE) | Control (Mean ± SE) | p Value Intergroup Differences | |
---|---|---|---|
Age (years) | 65.88 ± 12.6 | 63.84 ± 10.9 | 0.262991 |
Empty osteocytic lacunae (%) | 68.16 ± 10.57 | 40.91 ± 15.03 | 0.000019 |
Fatty infiltration (1–4) * | 3.5 ± 0.9 | 2.83 ± 0.83 | 0.08914 |
Medullary fibrosis (1–4) * | 2.75 ± 1.21 | 1.66 ± 0.98 | 0.03486 |
Heterotopic ossification (%) ⴕ | 25 ± 0.45 | 25 ± 0.45 | 1 |
Age (years) | 65.88 ± 12.6 | 63.84 ± 10.9 | - |
Ficat and Arlet Stage | Number of Samples Analyzed | Empty Osteocytic Lacunae (%) |
---|---|---|
I | 2 | 63 |
II | 1 | 80 |
III | 3 | 73 |
IV | 6 | 65 |
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Cardín-Pereda, A.; García-Sánchez, D.; Terán-Villagrá, N.; Alfonso-Fernández, A.; Fakkas, M.; Garcés-Zarzalejo, C.; Pérez-Campo, F.M. Osteonecrosis of the Femoral Head: A Multidisciplinary Approach in Diagnostic Accuracy. Diagnostics 2022, 12, 1731. https://doi.org/10.3390/diagnostics12071731
Cardín-Pereda A, García-Sánchez D, Terán-Villagrá N, Alfonso-Fernández A, Fakkas M, Garcés-Zarzalejo C, Pérez-Campo FM. Osteonecrosis of the Femoral Head: A Multidisciplinary Approach in Diagnostic Accuracy. Diagnostics. 2022; 12(7):1731. https://doi.org/10.3390/diagnostics12071731
Chicago/Turabian StyleCardín-Pereda, Adrián, Daniel García-Sánchez, Nuria Terán-Villagrá, Ana Alfonso-Fernández, Michel Fakkas, Carlos Garcés-Zarzalejo, and Flor María Pérez-Campo. 2022. "Osteonecrosis of the Femoral Head: A Multidisciplinary Approach in Diagnostic Accuracy" Diagnostics 12, no. 7: 1731. https://doi.org/10.3390/diagnostics12071731