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Volume 12
Issue 3
10.3390/diagnostics12030642
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Case Report

A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas

by
Maria Failla
1,2,*,
Rosario Caltabiano
1,
Antonio Longo
3,
Andrea Russo
3,
Michele Reibaldi
3,4,
Teresio Avitabile
3,
Eliana Piombino
2,
Cristina Colarossi
2,
Lorenzo Colarossi
2,
Elena Tirrò
5,6,
Paolo Vigneri
5,
Pietro Valerio Foti
7 and
Giuseppe Broggi
1
1
Department of Medical, Surgical Sciences and Advanced Technologies “G.F. Ingrassia”, Anatomic Pathology, University of Catania, 95123 Catania, Italy
2
Pathology Unit, Department of Experimental Oncology, Mediterranean Institute of Oncology, 95029 Viagrande, Italy
3
Eye Clinic, Department of Ophthalmology, University of Catania, 95123 Catania, Italy
4
Department of Surgical Sciences, Eye Clinic Section, University of Turin, 10126 Turin, Italy
5
Center of Experimental Oncology and Hematology, A.O.U. Policlinico “G. Rodolico—San Marco”, 95123 Catania, Italy
6
Department of Surgical, Oncological and Stomatological Sciences, University of Palermo, 90127 Palermo, Italy
7
Radiology I Unit, Department of Medical Surgical Sciences and Advanced Technologies G.F. Ingrassia, University Hospital Policlinico “G. Rodolico-San Marco”, 95123 Catania, Italy
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(3), 642; https://doi.org/10.3390/diagnostics12030642
Submission received: 18 November 2021 / Revised: 8 February 2022 / Accepted: 1 March 2022 / Published: 5 March 2022
(This article belongs to the Special Issue Eye Diseases: Diagnosis and Management)
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Abstract

Uveal melanoma (UM) is the most common primary intraocular tumor in adults and usually has a very poor prognosis. Histologically, UMs have been classified in epithelioid cell type, spindle cell type, and mixed cell type. Balloon cells are large pale cells that contain small, hyperchromatic, central nuclei with vesiculated, clear, and lipid-rich cytoplasm. A balloon cell morphology is infrequently observed in naevi and even less frequently in malignant melanomas of the skin, conjunctiva, ciliary body and choroid. In this regard, UMs that exhibit balloon cell features are generally those previously treated with proton beam irradiation and then enucleated, rather than those that directly underwent primary surgery. To the best of our knowledge, very few cases of primary UM showing extensive balloon cell morphology have been reported in scientific literature to date. We herein present an unusual case of primary UM with diffuse balloon cell changes in a 69-year-old woman.
Keywords: uveal melanoma; balloon cell; eye tumor; non-irradiated melanoma of the choroid uveal melanoma; balloon cell; eye tumor; non-irradiated melanoma of the choroid

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MDPI and ACS Style

Failla, M.; Caltabiano, R.; Longo, A.; Russo, A.; Reibaldi, M.; Avitabile, T.; Piombino, E.; Colarossi, C.; Colarossi, L.; Tirrò, E.; et al. A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas. Diagnostics 2022, 12, 642. https://doi.org/10.3390/diagnostics12030642

AMA Style

Failla M, Caltabiano R, Longo A, Russo A, Reibaldi M, Avitabile T, Piombino E, Colarossi C, Colarossi L, Tirrò E, et al. A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas. Diagnostics. 2022; 12(3):642. https://doi.org/10.3390/diagnostics12030642

Chicago/Turabian Style

Failla, Maria, Rosario Caltabiano, Antonio Longo, Andrea Russo, Michele Reibaldi, Teresio Avitabile, Eliana Piombino, Cristina Colarossi, Lorenzo Colarossi, Elena Tirrò, and et al. 2022. "A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas" Diagnostics 12, no. 3: 642. https://doi.org/10.3390/diagnostics12030642

APA Style

Failla, M., Caltabiano, R., Longo, A., Russo, A., Reibaldi, M., Avitabile, T., Piombino, E., Colarossi, C., Colarossi, L., Tirrò, E., Vigneri, P., Foti, P. V., & Broggi, G. (2022). A Case of Non-Irradiated Balloon Cell Melanoma of the Choroid: Expanding the Morphological Spectrum of Primary Uveal Melanomas. Diagnostics, 12(3), 642. https://doi.org/10.3390/diagnostics12030642

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