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Volume 12
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10.3390/diagnostics12030572
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Article

Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis

by
Takuki Sakaguchi
1,
Takaaki Sugihara
1,*,
Ken Ohnita
2,3,
Daisuke Fukuda
2,4,5,
Tetsuro Honda
6,
Ryohei Ogihara
1,
Hiroki Kurumi
1,
Kazuo Yashima
1 and
Hajime Isomoto
1,2,*
1
Department of Gastroenterology and Nephrology, Faculty of Medicine, Tottori University, Yonago 683-8504, Japan
2
Department of Gastroenterology, Nagasaki University Hospital, Nagasaki 852-8501, Japan
3
Shunkaikai Inoue Hospital, Nagasaki 850-0045, Japan
4
Department of Surgical Oncology, Graduate School of Biological Sciences, Nagasaki University, Nagasaki 852-8501, Japan
5
Fukuda Yutaka Clinic, Nagasaki 852-8107, Japan
6
Department of Gastroenterology, Nagasaki Harbor Medical Center, Nagasaki 850-8555, Japan
*
Authors to whom correspondence should be addressed.
Diagnostics 2022, 12(3), 572; https://doi.org/10.3390/diagnostics12030572
Submission received: 20 January 2022 / Revised: 17 February 2022 / Accepted: 21 February 2022 / Published: 23 February 2022
(This article belongs to the Special Issue Diagnostic Imaging of Gastrointestinal Diseases)
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Abstract

Duodenogastric reflux (DGR) causes bile reflux gastritis (BRG) and may develop into gastric cancer. DGR is classified as primary in non-operated stomachs or secondary to surgical intervention. Primary DGR and Helicobacter pylori (H. pylori) infection are reportedly related. However, the mechanism is not fully understood. This study aimed to elucidate the relationship between H. pylori infection and pyloric incompetence in a non-operated stomach. A total of 502 non-operated participants who underwent an upper intestinal endoscopy were prospectively enrolled. Endoscopic findings (EAC, endoscopic atrophy classification; nodular gastritis; xanthoma; fundic gland polyp; and incompetence of pylorus), sex, age, gastrin, pepsinogen (PG) I and PG II levels were evaluated. PG I/PG II ratio, anti-H. pylori-Ab positivity, and atrophic gastritis status were significantly different between the normal and incompetent pylori (p = 0.043, <0.001, and 0.001, respectively). Open-type atrophic gastritis was significantly higher in the incompetent pylori. Incompetence of the pylorus and EAC were moderately correlated (Cramer’s V = 0.25). Multivariate analysis revealed that the presence of anti-H. pylori-Ab was the only independent factor associated with the incompetence of the pylorus, with an adjusted odds ratio of 2.70 (95% CI: 1.47–4.94, p = 0.001). In conclusion, pyloric incompetence was associated with H. pylori infection and moderately correlated to the severity of atrophic gastritis in non-operated stomachs.
Keywords: duodenogastric reflux; bile reflux gastritis; Helicobacter pylori; atrophic gastritis; pylorus duodenogastric reflux; bile reflux gastritis; Helicobacter pylori; atrophic gastritis; pylorus

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MDPI and ACS Style

Sakaguchi, T.; Sugihara, T.; Ohnita, K.; Fukuda, D.; Honda, T.; Ogihara, R.; Kurumi, H.; Yashima, K.; Isomoto, H. Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis. Diagnostics 2022, 12, 572. https://doi.org/10.3390/diagnostics12030572

AMA Style

Sakaguchi T, Sugihara T, Ohnita K, Fukuda D, Honda T, Ogihara R, Kurumi H, Yashima K, Isomoto H. Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis. Diagnostics. 2022; 12(3):572. https://doi.org/10.3390/diagnostics12030572

Chicago/Turabian Style

Sakaguchi, Takuki, Takaaki Sugihara, Ken Ohnita, Daisuke Fukuda, Tetsuro Honda, Ryohei Ogihara, Hiroki Kurumi, Kazuo Yashima, and Hajime Isomoto. 2022. "Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis" Diagnostics 12, no. 3: 572. https://doi.org/10.3390/diagnostics12030572

APA Style

Sakaguchi, T., Sugihara, T., Ohnita, K., Fukuda, D., Honda, T., Ogihara, R., Kurumi, H., Yashima, K., & Isomoto, H. (2022). Pyloric Incompetence Associated with Helicobactor pylori Infection and Correlated to the Severity of Atrophic Gastritis. Diagnostics, 12(3), 572. https://doi.org/10.3390/diagnostics12030572

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