Next Article in Journal
Lanthanum Carbonate Opacities—A Systematic Review
Next Article in Special Issue
Urinary Activin A: A Novel Biomarker for Human Acute Kidney Injury
Previous Article in Journal
A Novel Computer-Aided Diagnostic System for Early Detection of Diabetic Retinopathy Using 3D-OCT Higher-Order Spatial Appearance Model
Previous Article in Special Issue
Urinary Dipstick Is Not Reliable as a Screening Tool for Albuminuria in the Emergency Department—A Prospective Cohort Study
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Diagnostics
Volume 12
Issue 2
10.3390/diagnostics12020462
diagnostics-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study

by
Yuji Shimizu
1,2,*,
Shin-Ya Kawashiri
3,4,
Yuko Noguchi
3,
Seiko Nakamichi
1,5,
Yasuhiro Nagata
3,4,
Takahiro Maeda
1,4 and
Naomi Hayashida
4,6
1
Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8501, Japan
2
Department of Cardiovascular Disease Prevention, Osaka Center for Cancer and Cardiovascular Diseases Prevention, Osaka 537-8511, Japan
3
Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
4
Leading Medical Research Core Unit, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki 852-8523, Japan
5
Nagasaki University Health Center, Nagasaki 852-8521, Japan
6
Division of Promotion of Collaborative Research on Radiation and Environmental Health Effects, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki 852-8523, Japan
*
Author to whom correspondence should be addressed.
Diagnostics 2022, 12(2), 462; https://doi.org/10.3390/diagnostics12020462
Submission received: 13 January 2022 / Revised: 7 February 2022 / Accepted: 8 February 2022 / Published: 11 February 2022
(This article belongs to the Special Issue Kidney Disease: Biomarkers, Diagnosis and Prognosis)
Browse Figures
Versions Notes

Abstract

Subclinical hypothyroidism (SCH) was reported to be associated with accelerating endothelial dysfunction, which is recognized as one of the upstream mechanisms that leads to glomerular injury (lower glomerular filtration rate (GFR)). SCH was also reported to be associated with hyperglycemia, which is associated with higher hemoglobin A1c (HbA1c) levels and induces endothelial dysfunction. Therefore, SCH status could influence the association between HbA1c and reduced eGFR. To clarify those associations, we conducted a prospective study of 1580 Japanese individuals who participated in an annual health check-up in 2014 with 2.8 years of follow-up. All participants had free triiodothyronine (T3) and free thyroxine (T4) levels in the normal range. Among study participants, 88 were diagnosed as having SCH. Even though no significant correlation was observed between HbA1c and annual change in estimated GFR among participants without SCH (multi-adjusted standardized parameter estimate (β) = 0.03, p = 0.250), a significant inverse association was observed among participants with SCH (β = −0.26, p = 0.014). When those analyses were performed among participants who were not taking glucose lowering medication, the observed associations were essentially the same: β = 0.03, p = 0.266 for participants without SCH and β = −0.32, p = 0.006 for participants with SCH, respectively. Therefore, SCH status could influence the association between HbA1c and renal function.
Keywords: subclinical hypothyroidism; thyroid stimulating hormone; triiodothyronine; HbA1c; renal function; GFR subclinical hypothyroidism; thyroid stimulating hormone; triiodothyronine; HbA1c; renal function; GFR

Share and Cite

MDPI and ACS Style

Shimizu, Y.; Kawashiri, S.-Y.; Noguchi, Y.; Nakamichi, S.; Nagata, Y.; Maeda, T.; Hayashida, N. Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study. Diagnostics 2022, 12, 462. https://doi.org/10.3390/diagnostics12020462

AMA Style

Shimizu Y, Kawashiri S-Y, Noguchi Y, Nakamichi S, Nagata Y, Maeda T, Hayashida N. Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study. Diagnostics. 2022; 12(2):462. https://doi.org/10.3390/diagnostics12020462

Chicago/Turabian Style

Shimizu, Yuji, Shin-Ya Kawashiri, Yuko Noguchi, Seiko Nakamichi, Yasuhiro Nagata, Takahiro Maeda, and Naomi Hayashida. 2022. "Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study" Diagnostics 12, no. 2: 462. https://doi.org/10.3390/diagnostics12020462

APA Style

Shimizu, Y., Kawashiri, S.-Y., Noguchi, Y., Nakamichi, S., Nagata, Y., Maeda, T., & Hayashida, N. (2022). Effect of Subclinical Hypothyroidism on the Association between Hemoglobin A1c and Reduced Renal Function: A Prospective Study. Diagnostics, 12(2), 462. https://doi.org/10.3390/diagnostics12020462

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop