Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy
Abstract
:1. Introduction
2. Materials and Methods
2.1. Subjects
2.2. OCTA Image Acquisition and Analysis
2.3. Statistical Analysis
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
References
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DM Duration | ||||
---|---|---|---|---|
Short Cohort: 0–5 Years (n = 571) | Medium Cohort: 6–10 Years (n = 306) | Long Cohort: Over 10 Years (n = 241) | p Values | |
Age, year | p < 0.001 (SC vs. MC and SC vs. LC) | |||
Mean (SD) [range] | 54.6 (11.7) [15–84] | 59.3 (10.2) [31–84] | 61.7 (10.3) [22–85] | p = 0.012 (MC vs. LC) |
Gender, No./total No. (%) | p = 0.072 (SC vs. MC) | |||
Female | 279/571 (48.9) | 169/306 (55.2) | 138/241 (57.3) | p = 0.029 (SC vs. LC) |
Male | 292/571 (51.1) | 137/306 (44.8) | 103/241 (42.7) | p = 0.634 (MC vs. LC) |
Body mass index (BMI) | ||||
Mean (SD) | 31.32 (7.27) | 30.37 (6.61) | 30.62 (7.56) | p = 0.067 |
HbA1c, % | p = 0.012 (SC vs. MC) | |||
Mean (SD) [range] | 7.64 (2.05) [4.1–20.4] | 7.76 (1.74) [4.4–15.1] | 7.97 (2.27) [5.4–27.1] | p = 0.001 (SC vs. LC) |
p = 0.387 (MC vs. LC) | ||||
Hypertension | p < 0.001 (SC vs. MC and SC vs. LC) | |||
No./total No. (%) | 303/571 (53.1) | 209/306 (68.3) | 177/241 (73.4) | p = 0.190 (MC vs. LC) |
Hyperlipidemia | p = 0.002 (SC vs. MC) | |||
No./total No. (%) | 299/571 (52.4) | 194/306 (63.4) | 156/241 (64.7) | p = 0.001 (SC vs. LC) |
p = 0.747 (MC vs. LC) | ||||
Diabetes treatment, No./total No. (%) | ||||
Diet control | 117/571 (20.5) | 26/306 (8.5) | 15/241 (6.2) | p < 0.001 (SC vs. MC and SC vs. LC) |
Oral medicine | 385/571 (67.4) | 215/306 (70.3) | 159/241 (66.0) | p = 0.158 (MC vs. LC) |
Insulin use | 69/571 (12.1) | 65/306 (21.2) | 67/241 (27.8) |
Perfusion Density | Vessel Density, mm−1 | FAZ Area, mm2 | FAZ Perimeter, mm | FAZ Circularity Index | |||||
---|---|---|---|---|---|---|---|---|---|
Statistic | 6 mm Patch | 1 mm Patch | Inner Ring | 6 mm Patch | 1 mm Patch | Inner Ring | |||
Short cohort (SC): | |||||||||
Mean (SD) | 0.360 (0.040) | 0.168 (0.054) | 0.381 (0.036) | 19.3 (1.9) | 9.4 (3.0) | 20.5 (2.0) | 0.287 (0.112) | 2.35 (0.51) | 0.643 (0.110) |
Medium cohort (MC): | |||||||||
Mean (SD) | 0.357 (0.038) | 0.157 (0.053) | 0.377 (0.034) | 19.0 (1.9) | 8.7 (2.9) | 20.3 (2.0) | 0.300 (0.118) | 2.43 (0.55) | 0.622 (0.112) |
Long cohort (LC): | |||||||||
Mean (SD) | 0.348 (0.041) | 0.160 (0.060) | 0.369 (0.037) | 18.6 (2.0) | 8.9 (3.3) | 19.7 (2.2) | 0.272 (0.119) | 2.35 (0.58) | 0.609 (0.114) |
p value | p = 0.119 (SC vs. MC) | p = 0.003 (SC vs. MC) | p = 0.172 (SC vs. MC) | p = 0.028 (SC vs. MC) | p = 0.001 (SC vs. MC) | p = 0.127 (SC vs. MC) | p = 0.105 (SC vs. MC) | p = 0.053 | p = 0.002 (SC vs. MC) |
p = 0.027 (MC vs. LC) | p = 0.441 (MC vs. LC) | p = 0.008 (MC vs. LC) | p = 0.011 (MC vs. LC) | p = 0.458 (MC vs. LC) | p = 0.003 (MC vs. LC) | p = 0.004 (MC vs. LC) | (*) | p = 0.268 (MC vs. LC) | |
p < 0.001 (SC vs. LC) | p = 0.062 (SC vs. LC) | p < 0.001 (SC vs. LC) | p < 0.001 (SC vs. LC) | p = 0.021 (SC vs. LC) | p < 0.001 (SC vs. LC) | p = 0.087 (SC vs. LC) | (*) | p < 0.001 (SC vs. LC) |
Perfusion Density | Vessel Density, mm−1 | FAZ Area, mm2 | FAZ Perimeter, mm | FAZ Circularity Index | |||||
---|---|---|---|---|---|---|---|---|---|
Variable | 6 mm Patch | 1 mm Patch | Inner Ring | 6 mm Patch | 1 mm Patch | Inner Ring | |||
Duration of diabetes | |||||||||
0–5 years | ref | ref | ref | ref | ref | ref | ref | ref | ref |
6–10 years | −0.025 | −0.068 | −0.014 | −0.006 | −0.077 | 0.000 | 0.061 | 0.070 | −0.049 |
p value | 0.447 | 0.038 | 0.673 | 0.860 | 0.018 | 0.989 | 0.069 | 0.037 | 0.145 |
10+ years | −0.065 | −0.007 | −0.071 | −0.059 | −0.014 | −0.060 | −0.045 | −0.021 | −0.061 |
p value | 0.061 | 0.839 | 0.036 | 0.075 | 0.672 | 0.075 | 0.193 | 0.550 | 0.076 |
Age | −0.212 | −0.153 | −0.261 | −0.349 | −0.164 | −0.336 | −0.091 | −0.006 | −0.201 |
p value | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | <0.001 | 0.008 | 0.866 | <0.001 |
Gender | 0.012 | 0.200 | 0.007 | 0.034 | 0.213 | 0.006 | −0.209 | −0.185 | −0.024 |
p value | 0.681 | <0.001 | 0.819 | 0.235 | <0.001 | 0.843 | <0.001 | <0.001 | 0.419 |
BMI | 0.005 | 0.085 | 0.000 | 0.056 | 0.111 | 0.051 | −0.057 | −0.092 | 0.075 |
p value | 0.865 | 0.005 | 0.995 | 0.057 | <0.001 | 0.087 | 0.065 | 0.004 | 0.016 |
HbA1c | −0.014 | −0.029 | −0.030 | −0.037 | −0.029 | −0.027 | −0.002 | 0.003 | −0.013 |
p value | 0.668 | 0.356 | 0.339 | 0.229 | 0.349 | 0.375 | 0.957 | 0.915 | 0.685 |
Hypertension | −0.082 | −0.035 | −0.062 | −0.004 | −0.021 | 0.020 | −0.007 | 0.021 | −0.012 |
p value | 0.010 | 0.264 | 0.050 | 0.897 | 0.501 | 0.511 | 0.832 | 0.526 | 0.705 |
Hyperlipidemia | 0.059 | 0.021 | 0.050 | 0.014 | 0.005 | 0.005 | 0.021 | 0.012 | 0.012 |
p value | 0.051 | 0.491 | 0.096 | 0.638 | 0.855 | 0.875 | 0.495 | 0.687 | 0.692 |
Treatment of diabetes | |||||||||
Oral medicine | 0.020 | 0.002 | 0.016 | −0.004 | −0.002 | −0.006 | −0.021 | −0.007 | −0.002 |
p value | 0.632 | 0.952 | 0.703 | 0.915 | 0.954 | 0.874 | 0.619 | 0.870 | 0.971 |
Insulin use | −0.004 | −0.004 | −0.001 | −0.030 | −0.010 | −0.025 | −0.016 | 0.006 | −0.023 |
p value | 0.937 | 0.931 | 0.979 | 0.482 | 0.824 | 0.552 | 0.727 | 0.891 | 0.602 |
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Qian, J.; Haq, Z.; Yang, D.; Jin, J.Q.; Stewart, J.M. Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy. Diagnostics 2022, 12, 3020. https://doi.org/10.3390/diagnostics12123020
Qian J, Haq Z, Yang D, Jin JQ, Stewart JM. Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy. Diagnostics. 2022; 12(12):3020. https://doi.org/10.3390/diagnostics12123020
Chicago/Turabian StyleQian, Jing, Zeeshan Haq, Daphne Yang, Joy Q. Jin, and Jay M. Stewart. 2022. "Duration of Diabetes as a Risk Factor for Retinal Microvasculature Alterations Detected with Optical Coherence Tomography Angiography in Patients without Clinical Retinopathy" Diagnostics 12, no. 12: 3020. https://doi.org/10.3390/diagnostics12123020