Correlation of Shear-Wave Elastography and Apparent Diffusion Coefficient Values in Breast Cancer and Their Relationship with the Prognostic Factors
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Group
2.2. Elastography Examination Technique
2.3. Diffusion MRI Examination Technique
2.4. Histopathological Analysis
2.5. Statistical Analysis
3. Results
4. Discussion
Study Limitations
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Estrogen Receptor | Progesterone Receptor | HER2 | Ki-67 Index | |
---|---|---|---|---|
Luminal A | + | +/− | − | <14% |
Luminal B | ||||
Luminal B (HER2 negative) | + | +/− | − | ≥14% |
Luminal B (HER2 positive) | + | +/− | + | |
HER2 + Subtype | − | − | + | |
Triple-negative Subtype | − | − | − |
Histopathological Type of Malignant Lesions | Number of Lesions |
---|---|
n | |
Malignant | 134 |
Invasive ductal carcinoma | 115 |
Invasive lobular carcinoma | 13 |
Ductal carcinoma in situ | 3 |
Malignant epithelial tumor | 1 |
Mucinous carcinoma | 1 |
Malignant phyllodes tumor | 1 |
Benign | 13 |
Fibrocystic changes | 4 |
Inflammatory changes | 1 |
Ductal hyperplasia | 1 |
Fat necrosis | 1 |
Apocrine metaplasia | 1 |
Phyllodes tumor | 1 |
Radial scar | 1 |
Fibroadenoma | 1 |
Sclerosing adenosis | 1 |
Fibrotic changes | 1 |
Characteristics | Number of Lesions n (%) | ADC (Median [IQR], ×10−3 cm2/s) | Elasticity (Median [IQR], kPA) | p Value |
---|---|---|---|---|
Estrogen | ||||
Positive | 108 (81.2%) | 0.84 (0.30) | 135.00 (24.00) | ADC → 0.323 Elasticity → 0.530 |
Negative | 25 (18.8%) | 0.94 (0.09) | 136.00 (24.50) | |
Progesterone | ||||
Positive | 82 (61.65%) | 0.88 (0.19) | 135.33 (28.00) | ADC → 0.211 Elasticity → 0.422 |
Negative | 41 (38.35%) | 0.94 (0.15) | 136.00 (23.00) | |
HER2 | ||||
Positive | 35 (26.31%) | 0.95 (0.17) | 134.00 (29.00) | ADC → 0.051 Elasticity → 0.812 |
Negative | 98 (73.69%) | 0.88 (0.25) | 130.00 (19.00) | |
Ki-67 Proliferation Index | ||||
High | 92 (69.17%) | 0.89 (0.18) | 137.00 (22.50) | ADC → 0.638 Elasticity → 0.240 |
Low | 41 (30.83%) | 0.91 (0.25) | 131.00 (22.50) |
Characteristics | Number of Lesions n (%) | ADC (Median ± [IQR], ×10−3 cm2/s) | Elasticity (Median ± [IQR], kPA) | Tumor Size (Median ± [IQR], mm) | Lesion Morphology | |
---|---|---|---|---|---|---|
Mass n (%) | Non-Mass n (%) | |||||
Malignant Lesions | 134 (91.15%) | 0.92 (0.18) | 135.00 (24.45) | 25.00 (22.00) | 117 (87.2%) | 17 (12.8%) |
Luminal A | 37 (27.61%) | 0.90 (0.29) | 131.00 (22.50) | 20.00 (17.00) | 33 (89.2%) | 4 (10.8%) |
Luminal B | 69 (51.49%) | 0.91 (0.19) | 135.00 (23.00) | 27.00 (24.50) | 59 (85.5%) | 10 (14.5%) |
HER2 positive | 12 (8.95%) | 0.93 (0.16) | 142.00 (20.00) | 21.50 (19.00) | 10 (83.3%) | 2 (16.7%) |
Triple-negative | 15 (11.19%) | 0.95 (0.09) | 136.00 (35.00) | 32.00 (17.00) | 14 (93.3%) | 1 (6.7%) |
Benign Lesions | 13 (8.84%) | 1.60 (0.55) | 27.00 (105.00) | 20.00 (39.50) | 6 (46.1%) | 7 (53.8%) |
All lesions | 147 (100%) | 0.93 (0.23) | 134.00 (25.75) | 34.50 (22.00) | 123(83.7%) | 24(16.3%) |
Lesion Morphology | ADC (Median ± [IQR], ×10−3 cm2/s) | Elasticity (Median ± [IQR], kPa) | p Value |
---|---|---|---|
Malignant Lesions | |||
Mass (n = 117) | 0.94 (0.25) | 126.00 (27.50) | ADC → 0.444 Elasticity → 0.718 |
Non-mass enhancement (n = 17) | 0.93 (0.28) | 135.00 (22.00) | |
Benign Lesions | |||
Mass (n = 6) | 1.60 (0.67) | 30.50 (94.75) | ADC → 0.836 Elasticity → 0.628 |
Non-mass enhancement (n = 7) | 1.57 (0.81) | 64.50 (129.00) |
ELASTICITY | |||||||
Year of Publication | Number of Malignant Lesions | ER and PR Positivity Cut-Off Value | Ki-67 Proliferation Index Cut-Off Value | HER2 Positivity Assessment Method | Elastography Type | Findings | |
Youk et al. [17] | 2013 | 166 | Method of Quick (Allred) Score (QS) | ≥14% | Score 3 or 2 and HER2 amplification | SWE |
|
Chang et al. [18] | 2013 | 337 | ≥10% | Not mentioned | Score 3 or 2 and HER2 amplification | SWE |
|
Choi et al. [19] | 2014 | 122 | Not mentioned | Not mentioned | Not mentioned | SWE |
|
Ganau et al. [20] | 2015 | 216 | ≥10% | ≥14% | Score 3 or 2 and HER2 amplification | SWE |
|
Makal et al. [21] | 2021 | 112 lesions (full malign) | ≥1% | ≥14% | Score 3 or 2 and HER2 amplification | SWE |
|
Our study | 133 | ≥1% | ≥14% | Score 3 or 2 and HER2 amplification | SWE |
| |
ADC | |||||||
Year of Publication | Number of Malignant Lesions | ER and PR positivity cut-off value | Ki-67 proliferation index cut-off value | HER2 positivity assessment method | b Value | Findings | |
Sung et al. [22] | 2009 | 62 | ≥10% | Not mentioned | Score 2 and 3 | 0 and 1000 |
|
Jeh et al. [23] | 2011 | 107 | ≥10% | ≥15% | Score 2 and 3 | 0, 750 and 1000 |
|
Choi et al. [24] | 2012 | 335 | ≥10% | ≥20% | Score 2 and 3 | 0 and 1000 |
|
Moutinho-Guilherme et al. [25] | 2018 | 100 | Method of Quick (Allred) Score (QS) | ≥20% | Score 3 or 2 and HER2 amplification | 0 and 700 |
|
Tezcan et al. [26] | 2019 | 83 | ≥10% | Not mentioned | Score 3 or 2 and HER2 amplification | 0 and 500 |
|
Ren et al. [27] | 2019 | 307 | ≥10% | ≥14% | Score 3 or 2 and HER2 amplification | 0 and 1000 |
|
Surov et al. [65] | 2019 | 661 | Not mentioned | ≥14% | Not mentioned | Different b values |
|
Linh et al. [29] | 2021 | 49 | ≥1% | ≥14% | Score 3 or 2 and HER2 amplification | 0 and 1000 |
|
Our study | 133 | ≥1% | ≥14% | Score 3 or 2 and HER2 amplification | 0 and 600 |
|
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Orguc, S.; Açar, Ç.R. Correlation of Shear-Wave Elastography and Apparent Diffusion Coefficient Values in Breast Cancer and Their Relationship with the Prognostic Factors. Diagnostics 2022, 12, 3021. https://doi.org/10.3390/diagnostics12123021
Orguc S, Açar ÇR. Correlation of Shear-Wave Elastography and Apparent Diffusion Coefficient Values in Breast Cancer and Their Relationship with the Prognostic Factors. Diagnostics. 2022; 12(12):3021. https://doi.org/10.3390/diagnostics12123021
Chicago/Turabian StyleOrguc, Sebnem, and Çağdaş Rıza Açar. 2022. "Correlation of Shear-Wave Elastography and Apparent Diffusion Coefficient Values in Breast Cancer and Their Relationship with the Prognostic Factors" Diagnostics 12, no. 12: 3021. https://doi.org/10.3390/diagnostics12123021