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Review

The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases

by
Yanfei Feng
1,†,
Zitong Yang
2,†,
Bodong Lv
3,* and
Xin Xu
4,*
1
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou 310053, China
2
Department of Urology, The Fourth Affiliated Hospital, Zhejiang University; Hangzhou 322000, China
3
Department of Urology, The Second Affiliated Hospital, Zhejiang University; Hangzhou 310009, China
4
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2022, 12(10), 2469; https://doi.org/10.3390/diagnostics12102469
Submission received: 14 September 2022 / Revised: 5 October 2022 / Accepted: 9 October 2022 / Published: 12 October 2022
(This article belongs to the Special Issue The Diagnostic and Therapeutic Value of RNAs in Human Diseases)
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Abstract

Circular RNAs (circRNAs) are a class of noncoding RNAs with closed-loop of single-stranded RNA structure. Although most of the circRNAs do not directly encode proteins, emerging evidence suggests that circRNAs play a pivotal and complex role in multiple biological processes by regulating gene expression. As one of the most popular circRNAs, circular homeodomain-interacting protein kinase 3 (circHIPK3) has frequently gained the interest of researchers in recent years. Accumulating studies have demonstrated the significant impacts on the occurrence and development of multiple human diseases including cancers, cardiovascular diseases, diabetes mellitus, inflammatory diseases, and others. The present review aims to provide a detailed description of the functions of circHIPK3 and comprehensively overview the diagnostic and therapeutic value of circHIPK3 in these certain diseases.
Keywords: circRNAs; circHIPK3; human diseases circRNAs; circHIPK3; human diseases

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MDPI and ACS Style

Feng, Y.; Yang, Z.; Lv, B.; Xu, X. The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases. Diagnostics 2022, 12, 2469. https://doi.org/10.3390/diagnostics12102469

AMA Style

Feng Y, Yang Z, Lv B, Xu X. The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases. Diagnostics. 2022; 12(10):2469. https://doi.org/10.3390/diagnostics12102469

Chicago/Turabian Style

Feng, Yanfei, Zitong Yang, Bodong Lv, and Xin Xu. 2022. "The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases" Diagnostics 12, no. 10: 2469. https://doi.org/10.3390/diagnostics12102469

APA Style

Feng, Y., Yang, Z., Lv, B., & Xu, X. (2022). The Diagnostic and Therapeutic Role of Circular RNA HIPK3 in Human Diseases. Diagnostics, 12(10), 2469. https://doi.org/10.3390/diagnostics12102469

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