Review Reports

Round 1

Reviewer 1 Report

In the present systematic review with meta-analysis about reader’s agreement in videocapsule endoscopy (VCE), Cortegoso Valdivia et al showed that most of studies reported a low inter- and intra-observer agreement and high heterogeneity among studies.

Some types of small bowel lesions are more prone to misdiagnosis. In this meta-analysis, several types of indications have been pooled and, therefore, this may explain the very high heterogeneity. Therefore I suggest, if possible, to perform sub-analyses by aggregating data/studies according to the different indication/finding of VCE.

Please update literature search (December 2021 is quite outdated).

Author Response

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Author Response File: Author Response.doc

Reviewer 2 Report

Well written study and meta-analysis. I do not have major comments, just two points that need clarification by the authors

1) What does the I-CARE group stand for? I know that there is an i-care study organized by GETAID for IBD patients, but I do not think this is the same group. Please clarify

2) Most of the readers do not know what inter and intra-obsever agreemnt mean. I think that the authors need to clarify these terms better in the Introduction or Methods and also distinguish better the two terms in the Discussion

Author Response

Please see the attachment

Author Response File: Author Response.doc

Round 2

Reviewer 1 Report

Answers were fine