Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis

Canberk, Sule; Barroca, Helena; Girão, Inês; Aydın, Ozlem; Uguz, Aysun; Erdogan, Kıvılcım; Tastekin, Ebru; Bongiovanni, Massimo; Soares, Paula; Máximo, Valdemar; Schmitt, Fernando

doi:10.3390/diagnostics12010179

Open AccessArticle

Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis

by

Sule Canberk

^1,2,3,*

,

Helena Barroca

⁴

,

Inês Girão

⁵,

Ozlem Aydın

⁶,

Aysun Uguz

⁷,

Kıvılcım Erdogan

⁷,

Ebru Tastekin

⁸,

Massimo Bongiovanni

⁹

,

Paula Soares

^1,2,10

,

Valdemar Máximo

^1,2,10

and

Fernando Schmitt

^2,10,11

¹

Instituto de Investigação e Inovação em Saúde (i3S), University of Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal

²

Institute of Molecular Pathology and Immunology of the University of Porto (Ipatimup), Rua Júlio Amaral de Carvalho 45, 4200-135 Porto, Portugal

³

Abel Salazar Biomedical Sciences Institute (ICBAS), University of Porto, Rua Jorge de Viterbo Ferreira 228, 4050-313 Porto, Portugal

⁴

Department of Pathology and Oncology, Centro Hospitalar São João, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal

⁵

Department of Biomedicine and Medicine, University of Algarve, 8005-139 Faro, Portugal

⁶

Department of Pathology, Medical Faculty, Acibadem University, Istanbul 34684, Turkey

⁷

Department of Pathology, Medical Faculty, Çukurova University, Adana 01330, Turkey

⁸

Department of Pathology, Medical Faculty, Trakya University, Edirne 22030, Turkey

⁹

Synlab Pathology, Rue du Liseron 5, 1006 Lausanne, Switzerland

¹⁰

Department of Pathology, Faculty of Medicine of the University of Porto (FMUP), Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal

¹¹

CINTESIS@RISE, Alameda Professor Hernâni Monteiro, 4200-319 Porto, Portugal

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^*

Author to whom correspondence should be addressed.

Diagnostics 2022, 12(1), 179; https://doi.org/10.3390/diagnostics12010179

Submission received: 2 November 2021 / Revised: 15 December 2021 / Accepted: 6 January 2022 / Published: 12 January 2022

(This article belongs to the Section Pathology and Molecular Diagnostics)

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Abstract

Background: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk of malignancy ratios (ROMs) was given in ranges and calculated by 2 different ways. Sensitivity, specificity, PPV, NPV and DA ratios were calculated using histologic diagnosis as the gold standard; Results: Among a total of 405 specimens, the distribution of cases for each category was, 44 (11%) for ND, 204 (50%) for B category, 40 (10%) for AUS/FLUS, 36 (9%) for FN/SFN, 24 (6%) for SFM and 57 (14%) for M categories. 153 cases have a histological diagnosis. The ratio of surgery was 23% in ND, 16% in the B, 45% for AUS/FLUS, 75% for SFN/FN and 92% for SFM and 75% in M categories; Conclusions: The data underlines the high ROM values in paediatric population which might be clinically meaningful. The high rate of malignancy of the cohort of operated patients (50%) also underlines the need of better preoperative indicators for stratification. Considering that more than half of the nodules in AUS/FLUS category were benign, direct surgery recommendation could be questionable as proposed in ATA 2015 guidelines.

Keywords: paediatric thyroid nodules; the Bethesda system for reporting thyroid cytology; thyroid cytology; TBSRTC; paediatric cytology; FNAC; Bethesda system

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MDPI and ACS Style

Canberk, S.; Barroca, H.; Girão, I.; Aydın, O.; Uguz, A.; Erdogan, K.; Tastekin, E.; Bongiovanni, M.; Soares, P.; Máximo, V.; et al. Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis. Diagnostics 2022, 12, 179. https://doi.org/10.3390/diagnostics12010179

AMA Style

Canberk S, Barroca H, Girão I, Aydın O, Uguz A, Erdogan K, Tastekin E, Bongiovanni M, Soares P, Máximo V, et al. Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis. Diagnostics. 2022; 12(1):179. https://doi.org/10.3390/diagnostics12010179

Chicago/Turabian Style

Canberk, Sule, Helena Barroca, Inês Girão, Ozlem Aydın, Aysun Uguz, Kıvılcım Erdogan, Ebru Tastekin, Massimo Bongiovanni, Paula Soares, Valdemar Máximo, and et al. 2022. "Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis" Diagnostics 12, no. 1: 179. https://doi.org/10.3390/diagnostics12010179

APA Style

Canberk, S., Barroca, H., Girão, I., Aydın, O., Uguz, A., Erdogan, K., Tastekin, E., Bongiovanni, M., Soares, P., Máximo, V., & Schmitt, F. (2022). Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis. Diagnostics, 12(1), 179. https://doi.org/10.3390/diagnostics12010179

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Performance of the Bethesda System for Reporting Thyroid Cytology in Multi-Institutional Large Cohort of Pediatric Thyroid Nodules: A Detailed Analysis

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