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Volume 11
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10.3390/diagnostics11081376
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Review

Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases

by
Charlotte Thomas
1,2,3,*,†,
Matthieu Minty
1,2,3,*,†,
Alexia Vinel
1,2,3,
Thibault Canceill
2,3,4,
Pascale Loubières
1,2,
Remy Burcelin
1,2,
Myriam Kaddech
2,3,
Vincent Blasco-Baque
1,2,3,† and
Sara Laurencin-Dalicieux
2,3,5,†
1
INSERM UMR 1297 Inserm, Institut des Maladies Métaboliques et Cardiovasculaires (I2MC), Avenue Jean Poulhès 1, CEDEX 4, 31432 Toulouse, France
2
Faculté de Chirurgie Dentaire, Université Paul Sabatier III (UPS), 118 Route de Narbonne, CEDEX 9, 31062 Toulouse, France
3
Service d’Odontologie Rangueil, CHU de Toulouse, 3 Chemin des Maraîchers, CEDEX 9, 31062 Toulouse, France
4
UMR CNRS 5085, Centre Interuniversitaire de Recherche et d’Ingénierie des Matériaux (CIRIMAT), Université Paul Sabatier, 35 Chemin des Maraichers, CEDEX 9, 31062 Toulouse, France
5
INSERM UMR 1295, Centre d’Epidémiologie et de Recherche en Santé des Populations de Toulouse (CERPOP), Epidémiologie et Analyse en Santé Publique, Risques, Maladies Chroniques et Handicaps, 37 Allées Jules Guesdes, 31000 Toulouse, France
*
Authors to whom correspondence should be addressed.
†
These authors contributed equally to this work.
Diagnostics 2021, 11(8), 1376; https://doi.org/10.3390/diagnostics11081376
Submission received: 15 July 2021 / Revised: 28 July 2021 / Accepted: 28 July 2021 / Published: 30 July 2021
(This article belongs to the Section Diagnostic Microbiology and Infectious Disease)
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Abstract

The oral cavity is host to a complex and diverse microbiota community which plays an important role in health and disease. Major oral infections, i.e., caries and periodontal diseases, are both responsible for and induced by oral microbiota dysbiosis. This dysbiosis is known to have an impact on other chronic systemic diseases, whether triggering or aggravating them, making the oral microbiota a novel target in diagnosing, following, and treating systemic diseases. In this review, we summarize the major roles that oral microbiota can play in systemic disease development and aggravation and also how novel tools can help investigate this complex ecosystem. Finally, we describe new therapeutic approaches based on oral bacterial recolonization or host modulation therapies. Collaboration in diagnosis and treatment between oral specialists and general health specialists is of key importance in bridging oral and systemic health and disease and improving patients’ wellbeing.
Keywords: oral microbiota; systemic disease; dysbiosis; periodontitis; endotoxemia; inflammation oral microbiota; systemic disease; dysbiosis; periodontitis; endotoxemia; inflammation

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MDPI and ACS Style

Thomas, C.; Minty, M.; Vinel, A.; Canceill, T.; Loubières, P.; Burcelin, R.; Kaddech, M.; Blasco-Baque, V.; Laurencin-Dalicieux, S. Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases. Diagnostics 2021, 11, 1376. https://doi.org/10.3390/diagnostics11081376

AMA Style

Thomas C, Minty M, Vinel A, Canceill T, Loubières P, Burcelin R, Kaddech M, Blasco-Baque V, Laurencin-Dalicieux S. Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases. Diagnostics. 2021; 11(8):1376. https://doi.org/10.3390/diagnostics11081376

Chicago/Turabian Style

Thomas, Charlotte, Matthieu Minty, Alexia Vinel, Thibault Canceill, Pascale Loubières, Remy Burcelin, Myriam Kaddech, Vincent Blasco-Baque, and Sara Laurencin-Dalicieux. 2021. "Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases" Diagnostics 11, no. 8: 1376. https://doi.org/10.3390/diagnostics11081376

APA Style

Thomas, C., Minty, M., Vinel, A., Canceill, T., Loubières, P., Burcelin, R., Kaddech, M., Blasco-Baque, V., & Laurencin-Dalicieux, S. (2021). Oral Microbiota: A Major Player in the Diagnosis of Systemic Diseases. Diagnostics, 11(8), 1376. https://doi.org/10.3390/diagnostics11081376

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